L-Homocystine

L-Homocystine
  • CAS No.:626-72-2
Other grades of this product :
L-Homocystine Basic information
Product Name:L-Homocystine
Synonyms:(2S,2'S)-2,2'-Diamino-(4,4'-dithiobisbutyric acid);3,3'-(Dithiobismethylene)bisalanine;4,4'-Dithiobis[(2S)-2-aminobutanoic acid];4,4'-Dithiobis[(S)-2-aminobutanoic acid];4,4'-Dithiobis[(S)-2-aminobutyric acid];(2S,2'S)-4,4'-Disulfanediylbis(2-aMinobutanoic acid);(2S,2'S)-4,4'-Dithiobis[2-aMinobutanoic Acid];[S-(R*,R*)]-4,4'-Dithiobis[2-aMinobutanoic Acid]
CAS:626-72-2
MF:C8H16N2O4S2
MW:268.35
EINECS:210-962-5
Product Categories:Amines;Intermediates & Fine Chemicals;Amino Acids;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:626-72-2.mol
L-Homocystine Chemical Properties
Melting point 281-284 °C (dec.)(lit.)
alpha 77 º (c=1% in 1N HCl)
Boiling point 507.6±50.0 °C(Predicted)
density 1.443±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka1.90±0.10(Predicted)
BRN 1728583
InChIKeyZTVZLYBCZNMWCF-WDSKDSINSA-N
CAS DataBase Reference626-72-2(CAS DataBase Reference)
EPA Substance Registry SystemL-Homocystine (626-72-2)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 29309090
MSDS Information
ProviderLanguage
SigmaAldrich English
L-Homocystine Usage And Synthesis
Chemical PropertiesWhite powder
UsesIncreased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.
Purification MethodsThe acid (3g) is dissolved in freshly boiled H2O (30mL) under N2, cooled under N2 (all operations should be under N2), absolute EtOH (100mL) is added, the acid is filtered off, and a second crop is obtained by diluting the filtrate to 500mL with absolute EtOH, kept overnight in a refrigerator, filtered, washed with EtOH and dried in a vacuum. The D(R,R)-form has similar properties but is –ve in M HCl and +ve in H2O. [du Vigneaud & Patterson J Biol Chem 109 101 1935, du Vigneaud & Brown Biochemical Preparations 5 93, 95 1975, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2667-2670 1961, Beilstein 4 III 1643, 4 IV 3199, Koegel et al. J Am Chem Soc 77 5708 1955.]
L-Homocystine Preparation Products And Raw materials

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