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| Product Name: | KGN | | Synonyms: | 2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid;2-[(Biphenyl-4-yl)carbaMoyl]benzoic Acid;Kartogenin(KGN);4'-Phenylphthalanilic Acid;Kartogenin;KGN;2-([1,1'-biphenyl]-4-ylcarbaMoyl)benzoic acid;4′-Phenyl-phthalanilic acid (8CI) | | CAS: | 4727-31-5 | | MF: | C20H15NO3 | | MW: | 317.34 | | EINECS: | | Product Categories: | Inhibitors;API | | Mol File: | 4727-31-5.mol |
| Melting point | 272 °C | | Boiling point | 464.4±38.0 °C(Predicted) | | density | 1.289±0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMSO: >15mg/mL | | form | powder | | pka | 3.45±0.36(Predicted) | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | | InChIKey | SLUINPGXGFUMLL-UHFFFAOYSA-N |
| Hazard Codes | Xn,N | | Risk Statements | 22-36-50/53 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | HS Code | 2916310090 |
| Description | Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro. | | Uses | Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed. | | Biochem/physiol Actions | Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ. | | References | 1) Johnson et al. (2012), A stem cell-based approach to cartilage repair; Science, 336 717 |
| KGN Preparation Products And Raw materials |
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