Product

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

CAS No.：141942-85-0

Other grades of this product :

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Basic information

Product Name:	Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Synonyms:	(R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER;(R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE;(S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL;ETHYL (3R)-4-CYANO-3-HYDROXY-BUTANOATE;ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE;ETHYL (R)-4-CYANO-3-HYDROXYBUTANOATE
CAS:	141942-85-0
MF:	C7H11NO3
MW:	157.17
EINECS:	430-220-6
Product Categories:	Atorvastatin intermediates;chiral;Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds;INTERMEDIATESOFATORVASTATIN;API intermediates;Pharmaceutical Intermediates
Mol File:	141942-85-0.mol

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties

alpha	-5 º (neat)
Boiling point	270 °C(lit.)
density	1.114 g/mL at 25 °C(lit.)
refractive index	n20/D 1.448(lit.)
Fp	>230 °F
storage temp.	2-8°C
solubility	Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
pka	13.03±0.20(Predicted)
form	Liquid
Specific Gravity	1.114
color	Colorless to yellow
optical activity	[α]25/D 5°, neat
BRN	5328715
InChIKey	LOQFROBMBSKWQY-ZCFIWIBFSA-N
CAS DataBase Reference	141942-85-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	1
HS Code	29269090

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Usage And Synthesis

Chemical Properties	yellow liquid
Uses	Atorvastatin Intermediate
Uses	analgesic, antipyretic, and anti-inflammatory
Uses	(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester is used in a biocatalytic process for the synthesis of an atorvastatin intermediate and degredation products/impurities.
Application	Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease. Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Preparation Products And Raw materials

Raw materials	Butanoic acid, 4-cyano-3-hydroxy-, (3R)--->Ethyl 4-bromo-3-hydroxybutyrate-->Sodium cyanide-->Ethanol-->Ethyl 4-chloroacetoacetate
Preparation Products	(3R,5R)-6-Cyano-3,5-dihydroxy-hexanoic Acid tert-Butyl Ester

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873