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| 2-Aminothiazole Basic information |
| 2-Aminothiazole Chemical Properties |
| Melting point | 91-93 °C (lit.) | | Boiling point | 117 °C (15.002 mmHg) | | density | 1.241 (estimate) | | vapor pressure | <1 hPa (20 °C) | | refractive index | 1.5300 (estimate) | | Fp | 117°C/15mm | | storage temp. | Store below +30°C. | | solubility | 1 M HCl: soluble50mg/mL, clear (dark yellow-brown) | | pka | 5.36(at 20℃) | | form | Crystalline Powder, Grains, Lumps or Flakes | | color | Brown | | PH | 9.6 (100g/l, H2O, 20℃) | | Water Solubility | 100 g/L (20 ºC) | | Merck | 14,479 | | BRN | 105738 | | InChIKey | RAIPHJJURHTUIC-UHFFFAOYSA-N | | CAS DataBase Reference | 96-50-4(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Aminothiazole(96-50-4) | | EPA Substance Registry System | 2-Aminothiazole (96-50-4) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36-36/37-20/21/22 | | Safety Statements | 26-36/37-39-36 | | WGK Germany | 3 | | RTECS | XJ2100000 | | F | 8-9 | | Autoignition Temperature | 600 °C | | Hazard Note | Irritant | | TSCA | Yes | | HS Code | 29341000 | | Toxicity | LD50 orally in Rabbit: 480 mg/kg |
| 2-Aminothiazole Usage And Synthesis |
| Chemical Properties | brown crystalline powder, grains, lumps or flakes | | Uses | antithyroid agent | | Uses | 2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds. | | Uses | Usually used in the synthesis of 2-aminothiazole-modified silica gel，and aslo used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation. | | Definition | ChEBI: A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2. | | Synthesis Reference(s) | Journal of the American Chemical Society, 76, p. 693, 1954 DOI: 10.1021/ja01632a016 | | General Description | Light brown crystals or brown granular solid. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | 2-Aminothiazole reacts violently when nitrated with nitric or nitric-sulfuric acids. 2-Aminothiazole is also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. | | Fire Hazard | Flash point data for 2-Aminothiazole are not available; however, 2-Aminothiazole is probably combustible. | | Biochem/physiol Actions | 2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders. | | Safety Profile | Poison by ingestion andintraperitoneal routes. Mutation data reported.Spontaneous ignition occurs at 100°. Mixtures with nitricacid or nitric acid + sulfuric acid explode on heating.Incompatible with HNO3 and H2SO4. When heated todecomposition it emi | | Purification Methods | It crystallises from pet ether (b 100-120o), or EtOH. [Beilstein 27 III/IV 4574.] |
| 2-Aminothiazole Preparation Products And Raw materials |
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