N-Methylbenzene-1,2-diamine

CAS No.：4760-34-3

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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N-Methylbenzene-1,2-diamine Basic information

Product Name:	N-Methylbenzene-1,2-diamine
Synonyms:	2-(methylamino)aniline;2-amino-n-methylaniline;n-methyl-2-benzenediamine;n-methyl-o-phenylenediamin;N-methylbenzene-1,2-diamine;N-METHYL-1,2-PHENYLENEDIAMINE / N-METHYL-O-PHENYLENEDIAMINE;N-1-methyl-1,2-benzenediamine.hcl;(2-aminophenyl)-methyl-amine
CAS:	4760-34-3
MF:	C7H10N2
MW:	122.17
EINECS:	225-297-6
Product Categories:	Nitrogen Compounds;Organic Building Blocks;Miscellaneous;(intermediate of telmisartan);Polyamines
Mol File:	4760-34-3.mol

N-Methylbenzene-1,2-diamine Chemical Properties

Melting point	22 °C (lit.)
Boiling point	123-124 °C/10 mmHg (lit.)
density	1.075 g/mL at 25 °C (lit.)
refractive index	n20/D 1.612(lit.)
Fp	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	6.17±0.10(Predicted)
form	Liquid
color	Clear yellow to red to dark brown
InChIKey	RPKCLSMBVQLWIN-UHFFFAOYSA-N
CAS DataBase Reference	4760-34-3(CAS DataBase Reference)
EPA Substance Registry System	1,2-Benzenediamine, N-methyl- (4760-34-3)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	20/21/22-36/38-36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	ST2770000
HS Code	29215900

MSDS Information

Provider	Language
SigmaAldrich	English

N-Methylbenzene-1,2-diamine Usage And Synthesis

Uses	N-Methyl-1,2-phenylenediamine may be used in the following studies: One-pot synthesis of 1-methyl-2(hetero)arylbenzimidazoles. Preparation of 1-methyl-1H-benzimidazole-2(3H)-thione. Total synthesis of the angiotensin II receptor antagonist, telmisartan. Preparation of benzimidazoles from ketene dithioacetals.
Synthesis Reference(s)	Synthetic Communications, 19, p. 1381, 1989 DOI: 10.1080/00397918908054547
General Description	N-Methyl-1,2-phenylenediamine is an ortho-diamine. In situ generated diazonium cations of N-methyl-1,2-phenylenediamine were used for the electrochemical modification of glassy carbon electrode.

N-Methylbenzene-1,2-diamine Preparation Products And Raw materials

Preparation Products

2-AMINO-1-METHYLBENZIMIDAZOLE-->1-METHYLBENZIMIDAZOLE-->(1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE

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