GAMMA-LINOLENIC ACID ETHYL ESTER

CAS No.：31450-14-3

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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GAMMA-LINOLENIC ACID ETHYL ESTER Basic information

Product Name:	GAMMA-LINOLENIC ACID ETHYL ESTER
Synonyms:	6,9,12-OCTADECATRIENOIC ACID ETHYL ESTER;GAMMA-LINOLENIC ACID ETHYL ESTER;DELTA 6 CIS 9 CIS 12 CIS OCTADECATRIENOIC ACID ETHYL ESTER;6,9,12-Octadecatrienoic acid, ethyl ester, (6Z,9Z,12Z)-;γ-Linolenic acid ethyl ester, 6,9,12-Octadecatrienoic acid ethyl ester;Ethyl linolenate gamma;(6Z,9Z,12Z)-6,9,12-Octadecatrienoic acid ethyl ester;Ethyl gamma-linolenate
CAS:	31450-14-3
MF:	C20H34O2
MW:	306.48
EINECS:
Product Categories:
Mol File:	31450-14-3.mol

GAMMA-LINOLENIC ACID ETHYL ESTER Chemical Properties

Boiling point	390.6±31.0 °C(Predicted)
density	0.893±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	liquid
color	Colourless
Stability:	Light Sensitive

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

GAMMA-LINOLENIC ACID ETHYL ESTER Usage And Synthesis

Description

γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B₄ (LTB₄) receptor antagonist, inhibiting [³H]-LTB₄ binding to porcine neutrophil membranes with a K_i value of 1 μM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB₄-induced bronchoconstriction. GLA ethyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets.

Uses

γ-Linolenic Acid Ethyl Ester is used in biological studies for neoplasm inhibition of cultured carcinoma cells of human breast. This analog is also used in the evaluation of hypocholesterolemic activity in rats by comparing it with γ-Linolenic Acid (L467660).

GAMMA-LINOLENIC ACID ETHYL ESTER Preparation Products And Raw materials

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