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| 2-METHOXYESTRADIOL Basic information |
| Product Name: | 2-METHOXYESTRADIOL | | Synonyms: | 2-METHOXYESTRADIOL \ INHIBITOR OF CELL P ROLIFERATION AND ANGIOGENESIS;2-METHOXY-OESTRADIOL-(17BETA),(13S,17S)-2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL;2-Hydroxyestradiol 2-Methyl Ether;2-Methoxy-17b-estradiol;2-Methoxyestra-1,3,5(10)-triene-3,17b-diol;NSC 659853;Panzem;2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol | | CAS: | 362-07-2 | | MF: | C19H26O3 | | MW: | 302.41 | | EINECS: | | Product Categories: | Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids;Inhibitor;Inhibitors;2-ME2;Isolabel;APIs | | Mol File: | 362-07-2.mol |
| 2-METHOXYESTRADIOL Chemical Properties |
| Melting point | 188-190°C | | Boiling point | 464.4±45.0 °C(Predicted) | | density | 1.178±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO: 10 mg/mL | | form | crystalline | | pka | 10.29±0.60(Predicted) | | color | light yellow | | λmax | 286nm(EtOH)(lit.) | | InChIKey | CQOQDQWUFQDJMK-SSTWWWIQSA-N | | CAS DataBase Reference | 362-07-2(CAS DataBase Reference) |
| 2-METHOXYESTRADIOL Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | A natural metabolite of 17?Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a | | Uses | A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly | | Uses | 2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity. | | Uses | 2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2. | | Uses | 2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine
binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function. | | Definition | ChEBI: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2. | | Biological Activity | Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly. |
| 2-METHOXYESTRADIOL Preparation Products And Raw materials |
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