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| 4-Methoxyindole Basic information |
| 4-Methoxyindole Chemical Properties |
| Melting point | 69-70 °C (lit.) | | Boiling point | 181-183 °C/24 mmHg (lit.) | | density | 1.1135 (rough estimate) | | refractive index | 1.5310 (estimate) | | Fp | 181-183°C/24mm | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | ethanol: soluble50mg/mL, clear, faintly yellow | | pka | 17.22±0.30(Predicted) | | form | Crystalline Powder and/or Chunks | | color | White | | Sensitive | Light Sensitive | | BRN | 122456 | | InChIKey | LUNOXNMCFPFPMO-UHFFFAOYSA-N | | CAS DataBase Reference | 4837-90-5(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-Indole, 4-methoxy-(4837-90-5) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-24/25 | | WGK Germany | 3 | | Hazard Note | Irritant/Keep Cold | | HazardClass | KEEP COLD, LIGHT SENSITIVE | | HS Code | 29339900 |
| 4-Methoxyindole Usage And Synthesis |
| Chemical Properties | light brown to grey crystalline powder | | Uses | 4-Methoxyindole is a reactant for alpha-ethyltryptamines as dual dopamine-serotonin releasers. | | Application | Reactant for preparation of:GABA analogsSodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in DiabetesAnticancer agentsIntegrase strand-transfer inhibitors (INSTIs)Inhibitor of Proliferation of Colon Cancer CellsIsomeridianin G as GSK-3? inhibitorsHIV-1 integrase inhibitorsInhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)4-Methoxyindole was used for comparing the complexation reaction of β-cyclodextrin (β-CD) with pindolol using reversed-phase liquid chromatography. | | Synthesis Reference(s) | Journal of Heterocyclic Chemistry, 24, p. 1499, 1987 DOI: 10.1002/jhet.5570240602 | | Biotechnological Applications | 4-Methoxyindole is used in a variety of preparation procedures. It is a reactant involved in the synthesis of GABA analogs, HIV-1 integrase inhibitors, anticancer agents, sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors, integrase strand-transfer inhibitors (INSTIs), and isomeridianin G. Additionally, it is used in reverse-phase liquid chromatography analysis of the reaction of β-cyclodextrin and pindolol. |
| 4-Methoxyindole Preparation Products And Raw materials |
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