Other grades of this product :
| Isoprenaline hydrochloride Basic information |
| Product Name: | Isoprenaline hydrochloride | | Synonyms: | 2-benzenediol,4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-hydrochloride;3,4-dihydroxy-alpha-((isopropylamino)methyl)-benzylalcohohydrochloride;alpha-(isopropylaminomethyl)-3,4-dihydroxybenzylalcoholhydrochloride;norisodrinehydrochloride;proternol;N-ISOPROPYL-DL-NORADRENALINE HYDROCHLORIDE;(+/-)-ISOPROTERENOL HYDROCHLORIDE;ISOPROTERENOL HYDROCHLORIDE | | CAS: | 51-30-9 | | MF: | C11H18ClNO3 | | MW: | 247.72 | | EINECS: | 200-089-8 | | Product Categories: | AEROLONE;Other APIs;Adrenoceptor;API;Cardiovascular Series | | Mol File: | 51-30-9.mol |
| Isoprenaline hydrochloride Chemical Properties |
| Melting point | 165-175 °C (dec.)(lit.) | | Boiling point | 192°C (rough estimate) | | density | 1.2296 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | 2-8°C | | solubility | Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. | | form | White solid | | color | White to Off-White | | Water Solubility | Soluble | | BRN | 3917363 | | Stability: | Stable, but may be air and light sensitive. Incompatible with strong oxidizing agents. | | InChIKey | IROWCYIEJAOFOW-UHFFFAOYSA-N | | CAS DataBase Reference | 51-30-9(CAS DataBase Reference) | | EPA Substance Registry System | Isoproterenol hydrochloride (51-30-9) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 2 | | RTECS | DO1925000 | | F | 3-8-10 | | HS Code | 29225090 | | Toxicity | LD50 oral in rabbit: 3070mg/kg |
| Isoprenaline hydrochloride Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder. | | Uses | Isoproterenol is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator. | | Uses | Isoproterenol hydrochloride is used as a selective β-adrenergic agonist, increases cytosolic cAMP. | | Brand name | Isuprel (Hospira); Isuprel (Sanofi Aventis); Vapo-
ISO (Fisons). | | General Description | Odorless white crystalline powder. Slightly bitter taste. Aqueous solutions turn brownish-pink upon prolonged exposure to air. | | Air & Water Reactions | May be sensitive to exposure to air and light. . Water soluble. | | Reactivity Profile | An acid organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. | | Health Hazard | SYMPTOMS: Symptoms of exposure to Isoprenaline hydrochloride may include tremors, nervous apprehension, palpitations of the heart, epigastric distress, cardiac arrhythmias, myocardial necrosis, cardiac arrest, tachycardia, headache, flushing of the skin, anginal pain, nausea, dizziness, weakness, and sweating. | | Fire Hazard | Flash point data for Isoprenaline hydrochloride are not available. Isoprenaline hydrochloride is probably combustible. | | Biological Activity | Standard selective β -adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β 2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo . Also available as part of the β -Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™ . | | Biochem/physiol Actions | β-adrenoceptor agonist; increases cytosolic cAMP. |
| Isoprenaline hydrochloride Preparation Products And Raw materials |
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