4-Chlorobutyronitrile

CAS No.：628-20-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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4-Chlorobutyronitrile Basic information

Product Name:	4-Chlorobutyronitrile
Synonyms:	GAMMA-CHLOROPROPYL CYANIDE;4-CHLOROBUTYRONITRILE;4-CHLOROBUTANENITRILE;4-chloro-butanenitril;4-chloro-butyronitril;Butyronitrile, 4-chloro-;gamma-Chlorobutyronitrile;4-CHLOROBUTYRONITRILE 99% (GC)
CAS:	628-20-6
MF:	C4H6ClN
MW:	103.55
EINECS:	211-031-6
Product Categories:	API Intermediate;Aliphatics;Halogen compounds;Miscellaneous;C1 to C5;Cyanides/Nitriles;Nitrogen Compounds
Mol File:	628-20-6.mol

4-Chlorobutyronitrile Chemical Properties

Boiling point	195-197 °C (lit.)
density	1.095 g/mL at 20 °C
refractive index	n20/D 1.442(lit.)
Fp	185 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Ethyl Acetate (Slightly)
form	Liquid
Specific Gravity	1.158
color	Clear colorless to pale yellow
Water Solubility	immiscible
BRN	1633582
InChIKey	ZFCFBWSVQWGOJJ-UHFFFAOYSA-N
CAS DataBase Reference	628-20-6(CAS DataBase Reference)
NIST Chemistry Reference	Butanenitrile, 4-chloro-(628-20-6)
EPA Substance Registry System	4-Chlorobutyronitrile (628-20-6)

Safety Information

Hazard Codes	T,Xi
Risk Statements	25-36/37/38
Safety Statements	45-7-36/37/39
RIDADR	UN 3276 6.1/PG 3
WGK Germany	3
RTECS	ET9020000
Hazard Note	Irritant
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29269095

MSDS Information

Provider	Language
4-Chlorobutyronitrile	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Chlorobutyronitrile Usage And Synthesis

Chemical Properties	Clear Colourless Liquid
Uses	4-Chlorobutyronitrile (cas# 628-20-6) is a compound useful in organic synthesis.
General Description	A liquid. Flash point 85°F. Density about 9.7 lb / gal and practically insoluble in water (2 parts/100 parts water). Hence sinks in water. Vapors are heavier than air. Irritates the eyes but not to the skin. Releases hydrogen chloride, hydrogen cyanide, and hydrogen bromide gases when heated or involved in a fire.
Air & Water Reactions	Highly flammable. Practically insoluble in water.
Reactivity Profile	4-Chlorobutyronitrile may attack some forms of plastics [USCG, 1999].
Health Hazard	Chemical is moderately toxic. Inhalation causes irritation of nose and throat. Ingestion causes irritation of mouth and stomach. Contact with eyes causes irritation. Can penetrate the skin on prolonged contact; only slightly irritating.
Fire Hazard	Special Hazards of Combustion Products: Toxic and irritating hydrogen cyanide, hydrogen bromide, and hydrogen chloride may form in fires.

4-Chlorobutyronitrile Preparation Products And Raw materials

Raw materials	POTASSIUM CYANIDE-->1-Bromo-3-chloropropane-->Sodium cyanide-->Ethanol
Preparation Products	Cyclopropanecarboxylic acid-->4-Aminobutyric acid-->2-(3-BROMO-PROPYL)-1H-BENZOIMIDAZOLE-->4-(DIETHYLAMINO)BUTYLAMINE-->4-DIMETHYLAMINOBUTYLAMINE-->2-(Thien-2-yl)pyrrolidine-->5-PHENYL-3,4-DIHYDRO-2H-PYRROLE-->CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1)-->4-(Methylthio)butanenitrile-->4-aminobutyronitrile-->4-BROMOBUTYRONITRILE

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