3-Amino-5-phenylpyrazole

3-Amino-5-phenylpyrazole
  • CAS No.:1572-10-7

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
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3-Amino-5-phenylpyrazole Basic information
Product Name:3-Amino-5-phenylpyrazole
Synonyms:SALOR-INT L317837-1EA;5-amino-3-phenyl-pyrazol;JR-8809, 5-Phenyl-1H-pyrazole-3-ylamine, 97%;5-PHENYL-2H-PYRAZOL-3-YLAMINE;5-PHENYL-1H-PYRAZOL-3-AMINE;5-PHENYL-1H-PYRAZOL-3-YLAMINE;AKOS B003768;AKOS 92617
CAS:1572-10-7
MF:C9H9N3
MW:159.19
EINECS:
Product Categories:Building Blocks;Heterocyclic Building Blocks;Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Heterocyclic Compounds;Pyrazoles;pyrazole series
Mol File:1572-10-7.mol
3-Amino-5-phenylpyrazole Chemical Properties
Melting point 124-127 °C (lit.)
Boiling point 442.3±33.0 °C(Predicted)
density 1.238±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO, Methanol
pka14.80±0.10(Predicted)
form Powder or Crystals
color Red to brown
BRN 4947
InChIKeyPWSZRRFDVPMZGM-UHFFFAOYSA-N
CAS DataBase Reference1572-10-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
RTECS UQ6109000
Hazard Note Irritant
HS Code 29331990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
3-Amino-5-phenylpyrazole Usage And Synthesis
Chemical PropertiesOff-white to cream colored crystalline powder
Uses3-Amino-5-phenylpyrazole ((3-phenyl-1H-pyrazol-5-amine) may be used in the synthesis of the following:
  • Urea derivatives by reaction with azido(6-(benzofuran-2-yl)-2-methylpyridin-3-yl) methanone.
  • 2-Mercaptoacetamide analogs by treating with thioglycolic acid.
  • 3-(Substituentpyrimidayl)-5,6-benzocoumarins by treating with 3-(2′-formyl-1′-chlorovinyl)-5,6-benzocoumarin.
  • Substituted 2,7-diphenylpyrazolo[1,5-a]pyrimidine-5-carboxylic esters by reacting with substituted β-diketo esters.
  • N-ethoxycarbonylthiourea derivative by reacting with ethoxycarbonyl isothiocyanate.
  • Heterobiaryl pyrazolo[3,4-b]pyridines by reacting with indole-3-carboxaldehyde.
General Description3-Amino-5-phenylpyrazole (3-phenyl-1H-pyrazol-5-amine), an amino pyrazole derivative, is an aza-heterocyclic amine. It has been reported to be synthesized by heating either 3-amino-4-bromo- or 3-amino-5-phenylisothiazole in the presence of anhydrous hydrazine. On reaction with ZnCl2 it affords chlorido-tris(3-amino-5-phenyl-1Hpyrazole-N2)zinc (II) chloride.
3-Amino-5-phenylpyrazole Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Tetrahydrofuran-->n-Butyllithium-->Sodium acetate trihydrate-->Acetophenone-->Diisopropylamine-->Semicarbazide hydrochloride

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