Methyl 6-bromo-2-naphthoate

CAS No.：33626-98-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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Methyl 6-bromo-2-naphthoate Basic information

Product Name:	Methyl 6-bromo-2-naphthoate
Synonyms:	6-Bromo-2-Naphtoic Acid Methyl Ester;2-Bromo-6-naphthoic acid methylester;6-BROMO-2-NAPHTHALENECARBOXYLIC ACID METHYL ESTER;6-BROMO-2-NAPHTHOIC ACID METHYL ESTER;METHYL 6-BROMO-2-NAPHTHALENECARBOXYLATE;METHYL 6-BROMO-2-NAPHTHOATE;2-Naphthoic acid, 6-bromo, methyl ester;Methyl-6-bromo-2-naphtoate
CAS:	33626-98-1
MF:	C12H9BrO2
MW:	265.1
EINECS:	608-896-0
Product Categories:	Naphthalene series;Building Blocks;C12 to C63;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Aromatic Esters;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Intermediates of Adapalene;C12 to C63;Carbonyl Compounds;Esters;API;Others chemical reagents;blocks;Bromides;Carboxes;ADAPALENE
Mol File:	33626-98-1.mol

Methyl 6-bromo-2-naphthoate Chemical Properties

Melting point	123-126 °C (lit.)
Boiling point	357.0±15.0 °C(Predicted)
density	1.492±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly)
form	Crystalline Powder
color	Off-white to cream or light brown
BRN	2578943
InChIKey	JEUBRLPXJZOGPX-UHFFFAOYSA-N
CAS DataBase Reference	33626-98-1(CAS DataBase Reference)

Safety Information

Hazard Codes	C
Risk Statements	20/21/22-34
Safety Statements	24/25-45-36/37/39-27-26
WGK Germany	3
HS Code	29163990

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

Methyl 6-bromo-2-naphthoate Usage And Synthesis

Chemical Properties	Pale yellow or light brown powder
Uses	Methyl 6-Bromo-2-napthoate is used in the synthesis of Adapalene, a retinoid specific for RARβ and RARγ receptors.
Uses	Methyl 6-Bromo-2-napthoate (Adapalene USP Related Compound A) is used in the synthesis of Adapalene, a retinoid specific for RARβ and RARγ receptors.
Uses	Methyl 6-bromo-2-naphthoate may be used to synthesize: 6-vinyl-2-naphthalencarbaldehyde methyl 6-(3-tert-butyl-4-methoxyphenyl)-2-naphthoate methyl 6-[3-tert-butyl-4-[(tert-butyldiethylsilyl)oxy]-phenyl]-2-naphthoate methyl 6-[3-(1-adamantyl)-4-[(tert-butyldimethylsilyl)-oxy]phenyl]-2-naphthoate methyl 6-[3-(1-adamantyl)-4-[[(2,3-dimethyl-1,3-dioxolan-4-yl)methylloxy]phenyl]-2-naphthoate 2-bromo-6-(bromomethyl)naphthalene
General Description	Methyl 6-bromo-2-naphthoate undergoes aromatic Finkelstein reaction followed by hydrolysis to afford 6-iodo-2-naphthoic acid.

Methyl 6-bromo-2-naphthoate Preparation Products And Raw materials

Preparation Products

2,2'-Bis-(1-adaMantyl)-4,4'-diMethoxybiphenyl-->2-Acetyl-6-bromonaphthalene

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