2-Methylbenzimidazole

CAS No.：615-15-6

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Methylbenzimidazole Basic information

Product Name:	2-Methylbenzimidazole
Synonyms:	2-METHYL-1H-BENZO[D]IMIDAZOLE;2-METHYL-1H-BENZIMIDAZOLE;2-METHYLBENZIMIDAZOLE;AKOS 90363;1H-2-Methylbenzimidazol;1H-2-Methylbenzimidazole;2-methyl-1h-benzimidazol;2-methyl-benzimidazol
CAS:	615-15-6
MF:	C8H8N2
MW:	132.16
EINECS:	210-411-9
Product Categories:	Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Benzimidazoles;BENZIMIDAZOLE;Building Blocks;Heterocyclic Building Blocks
Mol File:	615-15-6.mol

2-Methylbenzimidazole Chemical Properties

Melting point	175-177 °C (lit.)
Boiling point	234.08°C (rough estimate)
density	1.1083 (rough estimate)
refractive index	1.6013 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Crystalline Powder
pka	6.19(at 25℃)
color	Light beige to brown
Water Solubility	slightly soluble
BRN	112264
InChIKey	LDZYRENCLPUXAX-UHFFFAOYSA-N
CAS DataBase Reference	615-15-6(CAS DataBase Reference)
NIST Chemistry Reference	1H-benzimidazole, 2-methyl-(615-15-6)
EPA Substance Registry System	1H-Benzimidazole, 2-methyl- (615-15-6)

Safety Information

Hazard Codes	Xn
Risk Statements	22-37/38-41-20/21/22
Safety Statements	26-39-45-44
WGK Germany	3
RTECS	DD9100000
TSCA	Yes
HS Code	29339990

MSDS Information

Provider	Language
2-Methyl-1H-benzo[d]imidazole	English
ACROS	English
SigmaAldrich	English
ALFA	English

2-Methylbenzimidazole Usage And Synthesis

Chemical Properties	light beige to brown crystalline powder
Uses	2-Methylbenzimidazole is an important pharmacophore widely used in medicinal chemistry for the synthesis of various antibacterial and antifungal agents. It can be used as a key precursor to synthesize substituted benzimidazo[1,2-a]quinolones. It can be used in the synthesis of reversible solid-to-liquid phase transition coordination polymer crystals. 2-Methylbenzimidazole also exhibits corrosion inhibition.
Synthesis Reference(s)	Journal of Heterocyclic Chemistry, 26, p. 1163, 1989 DOI: 10.1002/jhet.5570260447Chemical and Pharmaceutical Bulletin, 17, p. 1153, 1969 DOI: 10.1248/cpb.17.1153
Safety Profile	Poison by intravenous route. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

2-Methylbenzimidazole Preparation Products And Raw materials

Raw materials	o-Phenylenediamine-->4'-nitroacetoacetanilide-->2-(5-TERT-BUTYL-2-HYDROXYPHENYL)BENZOTRIAZOLE-->N,N-Diethylformamide-->2-Nitroaniline
Preparation Products	Vitamin B12-->4,5-Imidazoledicarboxylic acid-->Chlormidazole-->5-BROMO-2-METHYL-1H-BENZIMIDAZOLE

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