| 5-Chloropyrimidin-2-amine Basic information |
| Product Name: | 5-Chloropyrimidin-2-amine |
| Synonyms: | TIMTEC-BB SBB005486;5-CHLORO-2-PYRIMIDINAMINE;2-AMINO-5-CHLOROPYRIMIDINE;2-Amino-5-chloropyridine;5-chloropyrimidin-2-amine;2-Pyrimidinamine, 5-chloro- (9CI);5-chlorpyrimidin-2-amin;5-chloro-2-pyrimidinylamine |
| CAS: | 5428-89-7 |
| MF: | C4H4ClN3 |
| MW: | 129.55 |
| EINECS: | 226-581-2 |
| Product Categories: | Heterocycle-Pyrimidine series;Heterocyclic Building Blocks;PYRIMIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Building Blocks;Halogenated Heterocycles |
| Mol File: | 5428-89-7.mol |
| 5-Chloropyrimidin-2-amine Chemical Properties |
| Melting point | 235-238 °C (lit.) |
| Boiling point | 314.6±34.0 °C(Predicted) |
| density | 1.437±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 1.93±0.10(Predicted) |
| color | White to Almost white |
| BRN | 110914 |
| InChIKey | OQZMDDKDHRIGDY-UHFFFAOYSA-N |
| CAS DataBase Reference | 5428-89-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Amino-5-chloropyrimidine(5428-89-7) |
| EPA Substance Registry System | 2-Pyrimidinamine, 5-chloro- (5428-89-7) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-41 |
| Safety Statements | 26-36/37 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | UV6329500 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | Ⅲ |
| HS Code | 29335990 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ALFA | English |
| 5-Chloropyrimidin-2-amine Usage And Synthesis |
| Uses | 5-Chloropyrimidin-2-amine is an useful reagent of research interest in the preparation of JAK2 inhibitors for the treatment of myeloproliferative disorders and SIRT2 inhibitors for the treatment of Huntington''s disease. |
| Synthesis Reference(s) | Journal of the American Chemical Society, 64, p. 567, 1942 DOI: 10.1021/ja01255a030 |
| 5-Chloropyrimidin-2-amine Preparation Products And Raw materials |
| Raw materials | 2-CHLOROMALONALDEHYDE-->Mucochloric acid-->Guanidine nitrate-->Guanidine carbonate |
| Preparation Products | 2-Aminopyrimidine |
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