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| 2'-O-Methyladenosine Basic information |
| 2'-O-Methyladenosine Chemical Properties |
| Melting point | 200-202 C | | Boiling point | 623.8±65.0 °C(Predicted) | | density | 1.84±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly) | | form | Powder | | pka | 13.13±0.70(Predicted) | | color | White to Off-white | | Water Solubility | Soluble in water. | | λmax | 259nm(H2O)(lit.) | | InChIKey | FPUGCISOLXNPPC-YGHVBYMHSA-N | | CAS DataBase Reference | 2140-79-6(CAS DataBase Reference) |
| 2'-O-Methyladenosine Usage And Synthesis |
| Description | 2'-O-Methyladenosine (Cordysinin B) is a member of the class of adenosines that is adenosine in which the hydroxy group at position 2' is replaced by a methoxy group. It has been isolated from the mycelia of Cordyceps sinensis. It has a role as a fungal metabolite. It is a member of adenosines and an ether. It derives from an adenosine. analogue with antiviral properties, starting material for 2'-O'-methyl nucleotides. Potential metabolite of 2'-O-Me-cAMP. | | Chemical Properties | White Solid | | Uses | 2'-O-Methyladenosine is an analog of adenosine used to prepare nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. | | Uses | Adenosine analog. | | Preparation | preparation of 2′-O-MethyladenosineMethylation of adenosine with methyl iodide in anhydrous alkaline mediumAdenosine is treated with CH3I in an anhydrous alkaline medium at 0°C for 4 h. The major products of this reaction are monomethylated adenosine at either the 2′-O or 3′-O position (total of 64%) and the side products are dimethylated adenosine (2′,3′-O-dimethyladenosi, 21%, and N6-2′-O-dimethyladenosine, 11%). The ratio of 2′-O- and 3′-O-methyladenosine has been found to be 8 to 1. Therefore, this reaction preferentially favors the synthesis of 2′-O-methyladenosine. The monomethylated adenosine is isolated from reaction mixture by a silica gel column chromatography. Then the pure 2′-O-methyladenosine can be separated by crystallization in ethanol from the mixture of 2′-O and 3′-O-methylated isomers. The overall yield of 2′-O-methyladenosine is 42%.https://doi.org/10.1016/0304-4165(80)90276-7 | | Definition | 2'-O-Methyladenosine is nucleoside modification in which a methyl group is added to the 2' hydroxyl of the ribose moiety of adenosine. | | Biological Activity | 2'-O-Methyladenosine, a methylated adenine residue is found in urine of normals as well as in urine of adenosine deaminase (ADA) deficient patients. 2'-O-Methyladenosine exhibits unique hypotensive activities. |
| 2'-O-Methyladenosine Preparation Products And Raw materials |
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