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| Triethyl acetyl citrate Basic information |
| Product Name: | Triethyl acetyl citrate | | Synonyms: | 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, triethyl ester;1,2,3-Propanetricarboxylicacid,2-(acetyloxy)-,triethylester;2,3-propanetricarboxylicacid,2-(acetyloxy)-triethylester;ATEC;Citric acid, acetyl triethyl ester;Citric acid, triethyl ester, acetate;citricacid,acetyltriethylester;citricacid,triethylester,acetate | | CAS: | 77-89-4 | | MF: | C14H22O8 | | MW: | 318.32 | | EINECS: | 201-066-5 | | Product Categories: | Hydroxycarboxylic Acid Esters (Plasticizer);Functional Materials;Plasticizer | | Mol File: | 77-89-4.mol |
| Triethyl acetyl citrate Chemical Properties |
| Melting point | -42°C | | Boiling point | 228-229 °C/100 mmHg (lit.) | | density | 1.136 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.439(lit.) | | Fp | >230 °F | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble 1 in 140 of water; miscible with acetone,
ethanol, and propan-2-ol. | | form | neat | | color | Colourless Thick | | BRN | 1804947 | | CAS DataBase Reference | 77-89-4(CAS DataBase Reference) | | NIST Chemistry Reference | 1,2,3-Propanetricarboxylic acid, 2-acetoxy-, triethyl ester(77-89-4) | | EPA Substance Registry System | 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, triethyl ester (77-89-4) |
| Safety Statements | 23-24/25 | | WGK Germany | 1 | | RTECS | GE8225000 | | HS Code | 2918150000 |
| Triethyl acetyl citrate Usage And Synthesis |
| Chemical Properties | Acetyltriethyl citrate occurs as a clear, odorless, practically colorless
oily liquid. | | Uses | ATEC is produced by the reaction of citric acid triethyl ester
with acetic acid anhydride. It is used as a solvent plasticizer
for cellulose nitrate and cellulose acetate. | | Uses | Triethyl O-Acetylcitrate is used in the preparation of poly(lactic) acid biodegradable and flexible films, acting as a plasticizer. Also used in the synthesis of control-release capsules containing polymeric coatings. | | Production Methods | Acetyltriethyl citrate is prepared by the esterification of citric acid
with ethanol followed by acylation with acetic anhydride. | | Definition | Aqueous-based pharmaceutical coat-
ings.
| | General Description | Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Triethyl 2-acetylcitrate is widely used in hydrophilic adhesives for medications and in biodegradable composition for papermaking and nonwoven production. | | Pharmaceutical Applications | Acetyltriethyl citrate is used to plasticize polymers in formulated
pharmaceutical coatings. The coating applications include
capsules, tablets, beads and granules for taste masking, immediate
release, sustained-release and enteric formulations. It is also
used in diffusion-controlled release drug delivery systems. | | Safety | Acetyltriethyl citrate is used in oral pharmaceutical formulations
and is generally regarded as a nontoxic and nonirritating material.
However, ingestion of large quantities may be harmful.
LD50 (cat, oral): 8.5 g/kg
LD50 (mouse, IP): 1.15 g/kg
LD50 (rat, oral): 7 g/kg | | storage | Acetyltriethyl citrate should be stored in dry, closed containers at
temperatures not exceeding 388℃. When stored in accordance with
these conditions, acetyltriethyl citrate is a stable product. | | Incompatibilities | Acetyltriethyl citrate is incompatible with strong alkalis and
oxidizing materials. | | Regulatory Status | Approved in the USA for direct food contact in food films. |
| Triethyl acetyl citrate Preparation Products And Raw materials |
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