4-Hydroxy-6-(trifluoromethyl)pyrimidine Seven Chongqing Chemdad Co. ，Ltd

Product

4-Hydroxy-6-(trifluoromethyl)pyrimidine

CAS No.：1546-78-7

Other grades of this product :

4-Hydroxy-6-(trifluoromethyl)pyrimidine Basic information

Product Name:	4-Hydroxy-6-(trifluoromethyl)pyrimidine
Synonyms:	6-TRIFLUOROMETHYL-4-PYRIMIDINOL;6-(TRIFLUOROMETHYL)PYRIMIDIN-4-OL;4-HYDROXY-6-TRIFLUOROMETHYLPYRIMIDINE;4-PYRIMIDINOL, 6-(TRIFLUOROMETHYL)-;4-Hydroxy-6-(trifluormethyl)-pyrimidin;6-TRIFLUOROMETHYL-4-PYRIMIDINOL 98+%;6-Trifluoromethyl-4(1H)-pyrimidinone;4-Hydroxy-6-(trifluoromethyl)pyrimidine ,98%
CAS:	1546-78-7
MF:	C5H3F3N2O
MW:	164.09
EINECS:
Product Categories:	Boronic Acid;Heterocyclic Compounds;Pyrimidine series;Fluorinated pyrimidine derivatives;Pyrimidines;alcohol;Fluorine series
Mol File:	1546-78-7.mol

4-Hydroxy-6-(trifluoromethyl)pyrimidine Chemical Properties

Melting point	169-171 °C(lit.)
Boiling point	130.3±50.0 °C(Predicted)
density	1.55±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	6.41±0.40(Predicted)
form	Crystalline
color	White
Water Solubility	Solubility in methanol (almost transparency). Slightly soluble in water.
BRN	145548
CAS DataBase Reference	1546-78-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HazardClass	IRRITANT
HS Code	29335990

MSDS Information

Provider	Language
SigmaAldrich	English

4-Hydroxy-6-(trifluoromethyl)pyrimidine Usage And Synthesis

Chemical Properties	White powder
Uses	4-Hydroxy-6-(trifluoromethyl)pyrimidine is used as building block in chemical synthesis. Attributes Development Product Contact
Uses	4-Hydroxy-6-(trifluoromethyl)pyrimidine (6-(Trifluoromethyl)-4-pyrimidinol) may be used in the synthesis of 10-[3-(6-trifluoromethyl-pyrimidin-4-yloxy)-propoxy]-(20S)-camptothecin.
Synthesis Reference(s)	Journal of the American Chemical Society, 80, p. 5744, 1958 DOI: 10.1021/ja01554a041
General Description	4-Hydroxy-6-(trifluoromethyl)pyrimidine, a pyrimidine derivative, is a heterocyclic building block.

4-Hydroxy-6-(trifluoromethyl)pyrimidine Preparation Products And Raw materials

Raw materials	Ethanol-->Hydrochloric acid-->Ethyl acetate-->Methanol-->Sodium-->Sodium sulfate-->Hexane-->Ethyl 4,4,4-trifluoroacetoacetate-->Formamidine acetate-->FORMAMIDINE HYDROCHLORIDE
Preparation Products	4-Chloro-6-trifluoromethylpyrimidine

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