Nicotinoyl chloride hydrochloride

CAS No.：20260-53-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Nicotinoyl chloride hydrochloride Basic information

Product Name:	Nicotinoyl chloride hydrochloride
Synonyms:	3-pyridinecarbonylchloride,hydrochloride;3-PYRIDINECARBONYL CHLORIDE;3-PYRIDINOYL CHLORIDE HYDROCHLORIDE;3-PYRIDINECARBOXYLIC ACID CHLORIDE HYDROCHLORIDE;NICOTINIC ACID CHLORIDE HYDROCHLORIDE;NICOTINOYL CHLORIDE HYDROCHLORIDE;NICOTINYL CHLORIDE HYDROCHLORIDE;PYRIDINE-3-CARBONYL CHLORIDE HYDROCHLORIDE
CAS:	20260-53-1
MF:	C6H5Cl2NO
MW:	178.02
EINECS:	243-648-1
Product Categories:	Intermediates & Fine Chemicals;Nicotine Derivatives;Pyridine;C6;Heterocyclic Building Blocks;Pharmaceuticals;Nitrogen cyclic compounds;Pyridines;Heterocycles
Mol File:	20260-53-1.mol

Nicotinoyl chloride hydrochloride Chemical Properties

Melting point	151-157 °C(lit.)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	Crystalline Powder
color	White to off-white
Water Solubility	It decomposes in water.
Sensitive	Moisture Sensitive
BRN	3655772
CAS DataBase Reference	20260-53-1(CAS DataBase Reference)
EPA Substance Registry System	3-Pyridinecarbonyl chloride, hydrochloride (20260-53-1)

Safety Information

Hazard Codes	C
Risk Statements	34
Safety Statements	26-28-36/37/39-45
RIDADR	UN 3261 8/PG 2
WGK Germany	3
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29333990

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

Nicotinoyl chloride hydrochloride Usage And Synthesis

Chemical Properties	white to off-white crystalline powder
Uses	As a Nicotinic Acid analog, Nicotinoyl chloride hydrochloride can be used in the preparation of cardiovascular agents and renal drugs.
Uses	Nicotinoyl chloride hydrochloride was used in the preparation of 1-[5-O-tert-butyldimethylsilyl-2-deoxy-2-fluoro-3-O-(3-pyridylcarbonyl)-β-D-ribofuranosyl]uracil, bis(ethylenedithio)tetrathiafulvalene derivatives and 7,16-dinicotinoylated or 7,16-diisonicotinoylated compounds via reaction with tetraaza[14]annulene and its complexes.
Uses	Nicotinoyl chloride hydrochloride was used in the preparation of : 1-[5-O-tert-butyldimethylsilyl-2-deoxy-2-fluoro-3-O-(3-pyridylcarbonyl)-β-D-ribofuranosyl]uracil 7,16-dinicotinoylated and/or 7,16-diisonicotinoylated compounds via reaction with tetraaza[14]annulene and its complexes bis(ethylenedithio)tetrathiafulvalene derivatives

Nicotinoyl chloride hydrochloride Preparation Products And Raw materials

Preparation Products

Nicorandil-->N-Methoxy-N-methylnicotinamide-->NICOTINANILIDE-->MYRISTYL NICOTINATE-->nicotinic anhydride-->Hexyl nicotinate-->Pikamilone-->NICOTINYL CHLORIDE HYDROCHLORIDE-->(5-BROMO-PYRIDIN-3-YL)-METHANOL-->3-Iodopyridine

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