Product

(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione

CAS No.：168828-82-8

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(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione Basic information

Product Name:	(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione
Synonyms:	2-Oxazolidinone, 3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-(hydroxymethyl)-, (5R)-;3-(3-FLUORO-4-(4-MORPHOLINYL)PHENYL)-5-HYDROXYMETHYL-(5R)-2-OXAZOLIDIONE;(R)-3-(3-FLUORO-4-MORPHOLINOPHENYL)-5-(HYDROXYMETHYL)OXAZOLIDIN-2-ONE;R-N-(3-FLUORO-4-MORPHOLINYLPHENYL)-2-OXO-5-OXAZOLIDINYLMETHANOL;(5R)-3-[3-FLUORO-4-(4-MORPHOLINYL)PHENYL]-5-(HYDROXYMETHYL)-2-OXAZOLIDINONE;5-hydroxymethyl-2-ox azolidione;Linezolid impurity PNU100440;(R)-3-(3-fluoro-4-morpholinophenyl)
CAS:	168828-82-8
MF:	C14H17FN2O4
MW:	296.29
EINECS:	688-342-2
Product Categories:
Mol File:	168828-82-8.mol

(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione Chemical Properties

Melting point	110-112 °C
Boiling point	494.2±45.0 °C(Predicted)
density	1.361±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	14.05±0.10(Predicted)
color	White to Pale Red
CAS DataBase Reference	168828-82-8(CAS DataBase Reference)

Safety Information

MSDS Information

(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione Usage And Synthesis

Uses	[(R)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methanol is an intermediate in the synthesis of Linezolid Dimer (L466520), an impurity of the antibacterial agent Linezolid (L466500).

(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione Preparation Products And Raw materials

Raw materials	NA-->linezolid impurity-->3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE-->Carbamic acid, [3-fluoro-4-(4-morpholinyl)phenyl]-, ethyl ester-->4-(2-FLUORO-4-NITRO-PHENYL)-MORPHOLINE-->CARBON DIOXIDE-->(R)-Glycidyl butyrate-->3,4-Difluoronitrobenzene-->Triphosgene
Preparation Products	(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate

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