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| Phthalazine Basic information |
| Phthalazine Chemical Properties |
| Melting point | 89-92 °C(lit.) | | Boiling point | 189 °C29 mm Hg(lit.) | | density | 1.1509 (rough estimate) | | refractive index | 1.6231 (estimate) | | Fp | 178-180°C/15mm | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Crystalline Powder | | pka | 3.47(at 20℃) | | color | Slightly brown to beige | | Water Solubility | Soluble in water, methanol, chloroform. | | Merck | 14,7370 | | BRN | 109240 | | CAS DataBase Reference | 253-52-1(CAS DataBase Reference) | | NIST Chemistry Reference | Phthalazine(253-52-1) | | EPA Substance Registry System | Phthalazine (253-52-1) |
| Phthalazine Usage And Synthesis |
| Chemical Properties | SLIGHTLY BROWN TO BEIGE CRYSTALLINE POWDER | | Uses | Phthalazine is a heterocyclic organic compound isomeric with quinoxaline, cinnoline and quinazoline. Aminophthalazine compounds serve as effective phosphodiesterase (PDE) inhibitors. | | Uses | Phthalazine derivatives including copper and platinum complexes were induce the apoptosis in breast cancer cell lines and renal hyperemia. | | Definition | ChEBI: An azaarene that is the 2,3-diaza analogue of naphthalene. The parent of the class of phthalazines. | | Synthesis Reference(s) | Journal of Heterocyclic Chemistry, 2, p. 206, 1965 DOI: 10.1002/jhet.5570020219 | | Purification Methods | Phthalazine crystallises from diethyl ether or *benzene, and sublimes under a vacuum. The hydrochloride forms needles from EtOH with m 235-236o(dec) and the picrate has m 208-210o. [Armarego J Appl Chem 11 70 1961, Beilstein 23 H 174, 23 III/IV 1233.] |
| Phthalazine Preparation Products And Raw materials |
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