4-(3-ACRYLOYLOXY-N-PROP-1-YLOXY)BENZOIC ACID

CAS No.：245349-46-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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4-(3-ACRYLOYLOXY-N-PROP-1-YLOXY)BENZOIC ACID Basic information

Product Name:	4-(3-ACRYLOYLOXY-N-PROP-1-YLOXY)BENZOIC ACID
Synonyms:	4-(3-ACRYLOYLOXY-N-PROP-1-YLOXY)BENZOIC ACID;4-(3-(acryloyloxy)propoxy)benzoic acid;4-(3-(acryloyloxy)propyloxy)benzoic acid;4-(3-prop-2-enoyloxypropoxy)benzoic acid;Benzoic acid,4-[3-[(1-oxo-2-propen-1-yl)oxy]propoxy]-
CAS:	245349-46-6
MF:	C13H14O5
MW:	250.25
EINECS:
Product Categories:	API intermediates
Mol File:	245349-46-6.mol

4-(3-ACRYLOYLOXY-N-PROP-1-YLOXY)BENZOIC ACID Chemical Properties

Boiling point	428.1±25.0 °C(Predicted)
density	1.208±0.06 g/cm3(Predicted)
pka	4.44±0.10(Predicted)

Safety Information

MSDS Information

4-(3-ACRYLOYLOXY-N-PROP-1-YLOXY)BENZOIC ACID Usage And Synthesis

Preparation

The preparation of 4-(3-acryloyloxy-n-prop-1-yloxy)benzoic acid is as follows:8.1g Allyl 4- (3- (acryloyloxy) propoxy) benzoic acid,4.1 g of N-methylaniline,Add 0.28 g of palladium acetate and 0.66 g of triphenylphosphine to 50 mL of acetonitrile, andStir at room temperature overnight. The reaction solution is diluted with ethyl acetate,The extract was washed with 5% hydrochloric acid and saturated brine, dried over anhydrous sodium sulfate, the solid was filtered off, and the solvent was evaporated. The residue is purified by column chromatography (silica gel, developing solvent: dichloromethane) to yield 4.2 g of 4- (3- (Acryloyloxy) propoxy) benzoic acid(Yield: 80.0%, purity (HPLC): 93.0%) was obtained.

4-(3-ACRYLOYLOXY-N-PROP-1-YLOXY)BENZOIC ACID Preparation Products And Raw materials

Preparation Products

1,4-Bis-[4-(3-acryloyloxypropyloxy)benzoyloxy]-2-methylbenzene

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