| Chloromethyl pivalate Basic information |
| Product Name: | Chloromethyl pivalate |
| Synonyms: | Chloromethyl 2,2-dimethylpropanoate;Methanol, chloro-, pivalate;Chloromethyl Pivalate , (2,2-Dimethylpropanoic acid chlormetyl ester);ChloroMethyl pivalate, 99+% 100GR;Chloromethyl Trimethylacetate 2,2-Dimethylpropionic Acid Chloromethyl Ester Pivalic Acid Chloromethyl Ester Trimethylacetic Acid Chloromethyl Ester;ChloroMethyl pivalate 97%;Pivalic acid Methyl chloride;hloromethyl pivalate |
| CAS: | 18997-19-8 |
| MF: | C6H11ClO2 |
| MW: | 150.6 |
| EINECS: | 242-735-1 |
| Product Categories: | Other Products;API;Building Blocks;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Pharmaceutical Intermediates;Phosgene Derivatives;Miscellaneous;Pharmaceutical Intermediate;Esters;Organic Building Blocks |
| Mol File: | 18997-19-8.mol |
| Chloromethyl pivalate Chemical Properties |
| Melting point | |
| Boiling point | 146-148 °C (lit.) |
| density | 1.045 g/mL at 25 °C (lit.) |
| refractive index | n |
| Fp | 104 °F |
| storage temp. | Inert atmosphere,2-8°C |
| form | Liquid |
| Specific Gravity | 1.038 |
| color | Clear colorless to slightly yellow |
| Water Solubility | Miscible with most organic solvents. Immiscible with water. |
| BRN | 1560838 |
| InChIKey | GGRHYQCXXYLUTL-UHFFFAOYSA-N |
| CAS DataBase Reference | 18997-19-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanoic acid, 2,2-dimethyl-, chloromethyl ester(18997-19-8) |
| EPA Substance Registry System | Propanoic acid, 2,2-dimethyl-, chloromethyl ester (18997-19-8) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 10-20/21/22-36/37/38 |
| Safety Statements | 16-26-36-41-36/37/39 |
| RIDADR | UN 3272 3/PG 3 |
| WGK Germany | 3 |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29159000 |
| MSDS Information |
| Provider | Language |
|---|---|
| 2,2-Dimethylpropanoic acid chloromethyl ester | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Chloromethyl pivalate Usage And Synthesis |
| Chemical Properties | Clear colorless to slightly yellow liquid |
| Uses | Chloromethyl pivalate was used in the synthesis of pivaloyloxy methyl ester of ofloxacin as prodrug. It was used as the reagent during the synthesis of an isoindoline-annulated, tricyclic sultam library via microwave-assisted, continuous-flow organic synthesis. |
| General Description | Chloromethyl pivalate reacts with sodium salt of sulbactam to yield sulbactam pivoxil. It undergoes acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to yield bis(pivaloyloxymethyl) PMEA. |
| Chloromethyl pivalate Preparation Products And Raw materials |
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