3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
  • CAS No.:503615-03-0
Other grades of this product :

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Basic information
Description References
Product Name:3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Synonyms:3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone;5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone;Apixaban Intermediate3;5-morpholin-4-yl-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one;3-(Morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one    (Nitro MPDP);3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one;Apixaban Impurity 19;5-morpholino-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one
CAS:503615-03-0
MF:C15H17N3O4
MW:303.31
EINECS:
Product Categories:
Mol File:503615-03-0.mol
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Chemical Properties
Boiling point 506.5±50.0 °C(Predicted)
density 1.356
storage temp. Sealed in dry,Store in freezer, under -20°C
pka3.11±0.20(Predicted)
Safety Information
MSDS Information
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Usage And Synthesis
Description3-(4-Morpholinyl)-1-(4-nitrophenyl)-5, 6-dihydro-2(1H)-pyridinone is the intermediate for the synthesis of apixaban, which is an anticoagulant for the treatment of venous thromboembolic events. 
ReferencesChao, H. E., et al. "Synthesis of Apixaban." Chinese Journal of Pharmaceuticals (2014). https://en.wikipedia.org/wiki/Apixaban
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Preparation Products And Raw materials
Preparation ProductsApixaban Impurity 17

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