(R)-(+)-Propylene oxide

CAS No.：15448-47-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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(R)-(+)-Propylene oxide Basic information

Product Name:	(R)-(+)-Propylene oxide
Synonyms:	(r)-(+)-propyleneoxid;(2R)-2-methyloxirane;(R)-(+)-Propylene oxide, 98+%;(R)-2-Methyloxirane;Oxirane, 2-Methyl-,(2R)-;(R)-(+)-Propylene Oxide , 98.0%(GC);(R)-(+)-1,2-Propylene oxide for synthesis;(r)-epoxypropane
CAS:	15448-47-2
MF:	C3H6O
MW:	58.08
EINECS:	604-958-6
Product Categories:	chiral;Chiral Building Blocks;Glycidyl Compounds, etc. (Chiral);Oxiranes;Simple 3-Membered Ring Compounds;Synthetic Organic Chemistry;Chiral Compound
Mol File:	15448-47-2.mol

(R)-(+)-Propylene oxide Chemical Properties

Melting point	-111.91°C (estimate)
alpha	14 º (neat)
Boiling point	33-34 °C(lit.)
density	0.829 g/mL at 20 °C(lit.)
vapor pressure	588 hPa (20 °C)
refractive index	n20/D 1.366(lit.)
Fp	-31 °F
storage temp.	Store at <= 20°C.
solubility	405g/l
form	clear liquid
color	Colorless to Almost colorless
explosive limit	1.9-37%(V)
optical activity	[α]20/D +14°, neat
Water Solubility	Miscible with water and many organic solvents.
Merck	14,7856
BRN	79764
InChIKey	GOOHAUXETOMSMM-GSVOUGTGSA-N
LogP	0.03-0.085
CAS DataBase Reference	15448-47-2(CAS DataBase Reference)

Safety Information

Hazard Codes	F+,T
Risk Statements	12-25-2017/12/25
Safety Statements	45
RIDADR	UN 1280 3/PG 1
WGK Germany	3
RTECS	UJ2650000
Autoignition Temperature	430 °C DIN 51794
HS Code	2910 20 00
HazardClass	3
PackingGroup	I
Toxicity	LD50 orally in Rabbit: 380 mg/kg LD50 dermal Rabbit 1243 mg/kg

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

(R)-(+)-Propylene oxide Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

(R)-(+)-Propylene oxide is widely utilized in the manufacture of polyether polyols and propylene glycol, which is used to make the polyurethane plastics. It finds application as a fumigant for the sterilization of packaged foods and plastic medical instruments. Combine with ethanol, it used to make biological samples for electron microscopy. It also used in model aircraft and surface vehicles as a glow fuel.

(R)-(+)-Propylene oxide Preparation Products And Raw materials

Raw materials	propene-->(S)-(-)-Propylene oxide
Preparation Products	(R)-(-)-1,2-Propanediol-->(R)-(-)-PENTEN-2-OL-->(S)-1-Chloro-2-propanol-->(R)-1-Chloro-2-propanol-->(S)-(+)-1-Methoxy-2-propanol-->(S)-(-)-Propylene Carbonate

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