Other grades of this product :
| 1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate Basic information |
| Product Name: | 1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate | | Synonyms: | 1-(2-hydroxyethyl)-1-methylguanidine dihydrogen phosphate;CREATINOLFOSFATE;creatinol phosphate;2-[carbamimidoyl(methyl)amino]ethyl dihydrogen phosphate;CREATINOLO-PHOSPHATE;CREATINOLO-PHOSPHATEANDITSSODIUMSALT;1-[2-(Phosphonooxy)ethyl]-1-methylguanidine;Aplodan | | CAS: | 6903-79-3 | | MF: | C4H12N3O4P | | MW: | 197.13 | | EINECS: | 230-011-8 | | Product Categories: | | Mol File: | 6903-79-3.mol |
| 1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate Chemical Properties |
| Melting point | 244 °C(dec.) | | Boiling point | 244°C(lit.) | | density | 1.65±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | pka | 1.84±0.10(Predicted) | | form | powder to crystal | | color | White to Almost white | | InChIKey | FOIPWTMKYXWFGC-UHFFFAOYSA-N | | CAS DataBase Reference | 6903-79-3(CAS DataBase Reference) |
| 1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate Usage And Synthesis |
| Originator | Aplodan,Simes,Italy,1968 | | Manufacturing Process | In a reactor put 80 kg of polyphosphoric acid having the following
composition: H5P3O10 - 60%; (HPO3)6 - 10%; H4P2O7 - 15%; (HPO3)x - 10%;
total content in P2O5 about 83%; this is heated to about 160°C.Then 360 kg of creatinol phosphate are added to the polyphosphoric acid;
continue to heat for about two hours under vacuum until the reaction water is
eliminated.The molten mass is then poured into ethanol at 95°C, the solution cooled
down to 10°C and the precipitated product separated by centrifugation. The
resulting product is dissolved in the minimum quantity of warm water and the
solution poured into ethanol.Thus 297 kg of the phosphoric ester of the creatinol are obtained having these
characteristics: MP 240°C to 243°C.
| | Therapeutic Function | Cardiotonic |
| 1-(2-Hydroxyethyl)-1-methylguanidine dihydrogen phosphate Preparation Products And Raw materials |
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