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| 4-Bromomethylbenzoic acid Basic information |
| 4-Bromomethylbenzoic acid Chemical Properties |
| Melting point | 224-229 °C(lit.) | | Boiling point | 252.95°C (rough estimate) | | density | 1.5313 (rough estimate) | | refractive index | 1.5500 (estimate) | | storage temp. | Store below +30°C. | | form | Crystalline Powder | | pka | 4.10±0.10(Predicted) | | color | White to beige | | Water Solubility | Soluble in water. | | BRN | 1862870 | | InChIKey | CQQSQBRPAJSTFB-UHFFFAOYSA-N | | CAS DataBase Reference | 6232-88-8(CAS DataBase Reference) | | EPA Substance Registry System | Benzoic acid, 4-(bromomethyl)- (6232-88-8) |
| Hazard Codes | Xi,C | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | RIDADR | 3261 | | WGK Germany | 3 | | F | 19-21 | | Hazard Note | Irritant | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29163900 |
| 4-Bromomethylbenzoic acid Usage And Synthesis |
| Chemical Properties | white to beige crystalline powder | | Uses | 4-(Bromomethyl)benzoic Acid is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive agent. | | Uses | 4-(Bromomethyl)benzoic acid acts as an intermediate in the synthesis of eprosartan, which is used as an antihypertensive agent. Further, it is used in the preparation of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (temoporfin), which is a second generation photosensitizer. In addition to this, it is used in the preparation of 4-(5-arylidene-2,4-dioxothiazolidin-3-yl) methylbenzoic acids. | | Uses | 4-(Bromomethyl)benzoic acid was used in the chemical modification of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (temoporfin), second generation photosensitizer. It was also used in the synthesis of 4-(5-arylidene-2,4-dioxothiazolidin-3-yl) methylbenzoic acids. | | Purification Methods | Crystallise the acid from pKEst Me2CO. [Beilstein 9 IV 1745.] |
| 4-Bromomethylbenzoic acid Preparation Products And Raw materials |
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