2-Amino-4,6-dihydroxypyrimidine

CAS No.：56-09-7

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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2-Amino-4,6-dihydroxypyrimidine Basic information

Product Name:	2-Amino-4,6-dihydroxypyrimidine
Synonyms:	2-amino-6-hydroxy-4(1h)-pyrimidinon;2-amino-6-hydroxy-4(1H)-Pyrimidinone;2-AMino-4,6-dioxypyriMidine;2-AMino-6-hydroxy-4(3H)-pyriMidinone;NSC 15920;NSC 18692;2-aMino-6-hydroxypyriMidin-4(3H)-one;2-AMino-4,6-dihydroxypyriMidine, 97+%
CAS:	56-09-7
MF:	C4H5N3O2
MW:	127.1
EINECS:	200-256-5
Product Categories:	Amines;Aromatics;5-FOA;Bases & Related Reagents;Nucleotides;Heterocycles;PYRIMIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Nucleotides and Nucleosides;Pyrimidines;Heterocycle-Pyrimidine series
Mol File:	56-09-7.mol

2-Amino-4,6-dihydroxypyrimidine Chemical Properties

Melting point	>300 °C (lit.)
Boiling point	235.85°C (rough estimate)
density	1.4748 (rough estimate)
refractive index	1.5000 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Soluble in Aqueous Alkali.
form	Powder
pka	7.45±0.10(Predicted)
color	Off-white to light pink or light yellow
BRN	510297
InChIKey	AUFJTVGCSJNQIF-UHFFFAOYSA-N
CAS DataBase Reference	56-09-7(CAS DataBase Reference)
EPA Substance Registry System	2-Amino-6-hydroxy-4(1H)-pyrimidinone (56-09-7)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	24/25-36-26
WGK Germany	1
RTECS	UW7361000
TSCA	Yes
HS Code	29339900

MSDS Information

Provider	Language
2-Aminopyrimidine-4,6-diol	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Amino-4,6-dihydroxypyrimidine Usage And Synthesis

Description	2-Amino-4,6-dihydroxypyrimidine is a hydroxypyrimidine.
Chemical Properties	White Solid
Uses	Intermediate in the production of antimicrobial guanylsulfonamides.
Uses	2-Amino-4,6-dihydroxypyrimidine acts as an intermediate in the production of antimicrobial guanylsulfonamides. It also acts as an intermediate in pharmaceuticals and agrochemicals.
Synthesis	The synthesis of 2-Amino-4,6-dihydroxypyrimidine is as follows:A freshly-prepared sodiummethoxide solution in methanol (25 ml) was added to a round-bottomed flask containing guanidine hydrochloride(15 mmol), stirred for a few minutes, before dimethyl malonate (15 mmol)was slowly added. The mixture was heated under reflux for about 2-3hours. After evaporation of the solvent under reduced pressure, the resultingwhite solid was dissolved in a minimum amount of water and the pH adjusted to 6with 10% HCl. The precipitate obtained was filtered and washed with distilledwater and ethanol, respectively, to obtain pure 2-amino-4,6-pyrimidinediol.(Note: sodium methoxide solution was prepared by addition of small pieces ofsodium metal in methanol).Yield: 85%;solid, m.p. 195-197 °C.

2-Amino-4,6-dihydroxypyrimidine Preparation Products And Raw materials

Raw materials	Sodium ethoxide-->Guanidine nitrate
Preparation Products	Bensulfuron methyl-->2,5-Diamino-4,6-dichloropyrimidine-->2-Amino-4,6-dimethoxypyrimidine-->2,5-Diamino-4,6-dihydroxy-pyrimidine

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