Product

Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate

CAS No.：128625-52-5

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Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate Basic information

Product Name:	Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
Synonyms:	pybop?/td>;BENZOTRIAZOLYL-N-OXYTRIS-(DIMETHYLAMINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE);(BENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE;BENZOTRIAZOL-1-YL-OXYTRIPYRROLIDINPHOSPHONIUM HEXAFLUOROPHOSPHATE;Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate;BENZOTRIAZOLE-1-YL-OXY-TRIS-DIMETHYLAMINOPHOPHONIUM;BENZOTRIAZOL-1-YLOXYTRIS(PYRROLIDINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE;BENZOTRIAZOLE-1-YL-OXY-TRIS-(DIMETHYLAMINO)-PHOPHONIUM HEXAFLUOROPHOSPHATE
CAS:	128625-52-5
MF:	C18H28F6N6OP2
MW:	520.39
EINECS:	603-290-2
Product Categories:	Peptide Coupling Reagents;Peptide coupling agents;Amino Acid Derivatives;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);Peptide Synthesis;Phosphonium Compounds;Synthetic Organic Chemistry;Peptide;Miscellaneous Reagents;Aromatics;peptides
Mol File:	128625-52-5.mol

Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate Chemical Properties

Melting point	154-156 °C (dec.)(lit.)
density	1.438 at 20℃
vapor pressure	0-0Pa at 20-50℃
storage temp.	2-8°C
solubility	methanol: 25 mg/mL, clear
form	Fine Crystalline Powder
color	White to off-white
Sensitive	Moisture Sensitive
BRN	3584612
InChIKey	BYCLGHOAELJLOF-UHFFFAOYSA-M
LogP	-0.3 at 26℃ and pH3.5-3.7
CAS DataBase Reference	128625-52-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	37/38-44-36/37/38
Safety Statements	26-36-24/25-37/39
RIDADR	UN 1325 4.1/PG 2
WGK Germany	3
F	8-10-21
Hazard Note	Irritant
HS Code	29339980

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate Usage And Synthesis

Chemical Properties	Off-White Solid
Uses	One of the most convenient coupling reagents for peptide synthesis without carcinogenic by-products. It replaces BOP reagent. This is especially suitable for solid-phase peptide synthesis, avoids racemization.
Uses	1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.
Uses	Reagent for: Synthesis of single labeled oligonucleotides that fluoresce upon matched hybridization Generation of endocrine disruptor chemical binders Cycloaddition to template-assembled multivalent peptide conjugates
General Description	(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.

Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate Preparation Products And Raw materials

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