1,4-Bis(3-aminopropyl)piperazine

CAS No.：7209-38-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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1,4-Bis(3-aminopropyl)piperazine Basic information

Product Name:	1,4-Bis(3-aminopropyl)piperazine
Synonyms:	1,4-Piperazinedipropanamine;3-[4-(3-Aminopropyl)-1-piperazinyl]propylamine;N,N'-Bis(p-aminopropyl)piperazine;Piperazine, 1,4-bis(3-aminopropyl)-;1,4-DI(3-AMINOPROPYL)PIPERAZINE;1,4-BIS(3-AMINOPROPYL)PIPERAZINE;1,4-(BIS AMINOPROPYL) PIPERAZINE;1,4-PIPERAZINEBIS(PROPYLAMINE)
CAS:	7209-38-3
MF:	C10H24N4
MW:	200.32
EINECS:	230-589-1
Product Categories:	Cell Biology;Chemical Synthesis;Building Blocks;Heterocyclic Building Blocks;Piperazines;Heterocyclic Building Blocks;B;Bioactive Small Molecules;Building Blocks;C10
Mol File:	7209-38-3.mol

1,4-Bis(3-aminopropyl)piperazine Chemical Properties

Melting point	15 °C(lit.)
Boiling point	150-152 °C2 mm Hg(lit.)
density	0.973 g/mL at 25 °C(lit.)
vapor density	6.9 (vs air)
vapor pressure	0.133Pa at 25℃
refractive index	n20/D 1.502(lit.)
Fp	325 °F
form	clear liquid
pka	10.69±0.10(Predicted)
color	Colorless to Almost colorless
PH	11.7 at 20℃ and 1mg/L
Water Solubility	Fully miscible in water.
Sensitive	Air Sensitive
BRN	111747
LogP	-1.43 at 25℃ and pH12.5
Surface tension	39.96mN/m at 1g/L and 20℃
CAS DataBase Reference	7209-38-3(CAS DataBase Reference)
NIST Chemistry Reference	1,4-Bis(3-aminopropyl)piperazine(7209-38-3)
EPA Substance Registry System	1,4-Piperazinedipropanamine (7209-38-3)

Safety Information

Hazard Codes	C
Risk Statements	34
Safety Statements	26-27-28-36/37/39-45
RIDADR	UN 2735 8/PG 2
WGK Germany	3
RTECS	TK8700000
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	2933599590
Toxicity	LD50 ivn-mus: 3500 mg/kg CPBTAL 20,2459,72

MSDS Information

Provider	Language
1,4-Bis(3-aminopropyl)piperazine	English
ACROS	English
SigmaAldrich	English
ALFA	English

1,4-Bis(3-aminopropyl)piperazine Usage And Synthesis

Chemical Properties	colorless to yellow liquid
Uses	1,4-Bis(3-aminopropyl)piperazine was used to functionalize natural montmorillonite (M) and synthetic kanemite (K)1.
General Description	The thermodynamic parameters for protonation of 1,4-bis(3-aminopropyl)-piperazine (BAPP) were studied in aqueous solution using a potentiometric technique.
Safety Profile	Poison by intravenous route. Acorrosive material and a powerful irritant to skin, eyes, andmucous membranes. When heated to decomposition itemits toxic fumes of NOx.

1,4-Bis(3-aminopropyl)piperazine Preparation Products And Raw materials

Raw materials

Methanol-->Ammonia-->Piperazine-->Nickel-->Acrylonitrile

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