| (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate Basic information |
| Product Name: | (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate |
| Synonyms: | (S)-(+)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE P-TOLUENESULFONATE;(S)-5-HYDROXYMETHYL-2-PYRROLIDINONE P-TOLUENESULFONATE;(-)-L-PYROGLUTAMOL P-TOLUENESULFONATE;4-methylbenzenesulfonic acid [(2S)-5-oxo-2-pyrrolidinyl]methyl ester;(R)-Anabasine, >(S)-(+)-5-(hydroxymethyl)-2-pyrrolidinone P-tolu;TOLUENE-4-SULFONIC ACID (S)-5-OXO-PYRROLIDIN-2-YLMETHYL ESTER;>98%ee |
| CAS: | 51693-17-5 |
| MF: | C12H15NO4S |
| MW: | 269.32 |
| EINECS: | |
| Product Categories: | Chiral Building Blocks;Heterocyclic Building Blocks;Pyrrolidines |
| Mol File: | 51693-17-5.mol |
| (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate Chemical Properties |
| Melting point | 124-128 °C (lit.) |
| alpha | 8.5 º (c=1 in ethanol) |
| Boiling point | 504.8±23.0 °C(Predicted) |
| density | 1.275±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| pka | 15.34±0.40(Predicted) |
| form | Powder |
| color | Colorless to beige |
| optical activity | [α]20/D +8.5°, c = 1 in ethanol |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HS Code | 29339980 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ACROS | English |
| (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate Usage And Synthesis |
| Chemical Properties | colorless to beige powder |
| Uses | Serves as a building block in the synthesis of (R)- and (S)-diaminovaleric acids and of 5-azasemicorrin bidentate nitrogen ligands for enantioselective catalysis. |
| (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate Preparation Products And Raw materials |
| Raw materials | Ethyl L-pyroglutamate-->Methyl L-pyroglutamate-->L-Pyroglutaminol-->Tosyl chloride-->Tetrabutylammonium hydrogen sulfate-->L-Glutamic acid-->L-Pyroglutamic acid |
| Preparation Products | sacubitril |
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