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| 4,7-Dichloroquinoline Basic information |
| 4,7-Dichloroquinoline Chemical Properties |
| Melting point | 81-83 °C (lit.) | | Boiling point | 298.4 °F (148°C) | | density | 1.4178 (rough estimate) | | vapor pressure | 0.103Pa at 25℃ | | refractive index | 1.6300 (estimate) | | Fp | 164 °C | | storage temp. | 2-30°C | | solubility | chloroform: soluble50mg/mL, clear, colorless to greenish-yellow | | pka | 1.99±0.27(Predicted) | | form | Powder | | color | White to pale brown | | Water Solubility | insoluble | | BRN | 125359 | | InChIKey | HXEWMTXDBOQQKO-UHFFFAOYSA-N | | LogP | 3.193 at 25℃ | | CAS DataBase Reference | 86-98-6(CAS DataBase Reference) | | NIST Chemistry Reference | Quinoline, 4,7-dichloro-(86-98-6) | | EPA Substance Registry System | 4,7-Dichloroquinoline (86-98-6) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-22 | | WGK Germany | 3 | | RTECS | VB4200000 | | Hazard Note | Irritant | | TSCA | Yes | | HS Code | 29334910 |
| 4,7-Dichloroquinoline Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder | | Uses | 4,7-Dichloroquinoline is used in the synthesis of hybrid aminoquinoline-triazine derivatives that show anti-microbial activity. In addition, it is used in the synthesis of novel oxazolidinones as anti
-microbial agents showing efficacy against common bacterial strains. Chloroquinoline impurity. | | Uses | 4,7-Dichloroquinoline is used as a drug chloroquine phosphate intermediate. It was used in the synthesis of piperaquine. and as starting reagent in the synthesis of {3-amino-5-[(7-chloro-4-quinolyl)amino]phenyl}methanol. | | General Description | Chloroquine Related Compound A is an impurity of chloroquine, which is a 9-aminoquinoline drug that effectively inhibits viral infections in humans. | | Flammability and Explosibility | Notclassified | | Synthesis | 4,7-Dichloroquinoline is obtained by chlorination of 7-chloro-4-hydroxyquinoline.
| | Purification Methods | Crystallise the dichloroquinoline from MeOH or 95% EtOH. [Beilstein 20/7 V 316.] |
| 4,7-Dichloroquinoline Preparation Products And Raw materials |
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