D-2-Amino-4-methylpentanoic acid

CAS No.：328-38-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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D-2-Amino-4-methylpentanoic acid Basic information

Product Name:	D-2-Amino-4-methylpentanoic acid
Synonyms:	D-Leucine≥ 99.5% (anhydrous assay);(R)-(-)-LEUCINE;(R)-LEUCINE;(R)-2-AMINO-4-METHYLPENTANOIC ACID;(R)-2-AMINO-4-METHYLVALERIC ACID;D-LEU;D-LEUCINE;D-HOMO-VALINE
CAS:	328-38-1
MF:	C6H13NO2
MW:	131.17
EINECS:	206-327-7
Product Categories:	amnio acid;amino acid;Leucine [Leu, L];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;Amino Acids
Mol File:	328-38-1.mol

D-2-Amino-4-methylpentanoic acid Chemical Properties

Melting point	>300 °C(lit.)
alpha	-15.45 º (c=4, 6N HCl)
Boiling point	225.8±23.0 °C(Predicted)
density	1.2930 (estimate)
refractive index	-15 ° (C=4, 6mol/L HCl)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Aqueous Acid (Sparingly), Water (Slightly)
form	Crystalline Powder, Crystals, or Flakes
pka	2.55±0.21(Predicted)
color	White
optical activity	[α]23/D 14.7°, c = 2 in 5 M HCl
Water Solubility	24 g/L (25 ºC)
BRN	1721721
CAS DataBase Reference	328-38-1(CAS DataBase Reference)
NIST Chemistry Reference	D-Leucine(328-38-1)
EPA Substance Registry System	D-Leucine (328-38-1)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	22-24/25-36-26
WGK Germany	3
RTECS	OH2840000
TSCA	Yes
HS Code	29224995

MSDS Information

Provider	Language
D-2-Amino-4-methylpentanoic acid	English
ACROS	English
SigmaAldrich	English
ALFA	English

D-2-Amino-4-methylpentanoic acid Usage And Synthesis

Chemical Properties	White powder
Uses	D-Leucine is used in the formation of sterols. It is also used as a selectable marker.
Definition	ChEBI: The D-enantiomer of leucine.

D-2-Amino-4-methylpentanoic acid Preparation Products And Raw materials

Raw materials	DL-Leucine-->2-Oxazolidinone, 3-(4-methyl-1-oxopentyl)-4-(phenylmethyl)-, (4S)--->N-BENZYL-L-LEUCINE-->(2S)-2-AMINO-5-HEXENOIC ACID-->4-Methyl-2-oxovaleric acid-->H-D-LEU-NH2-->Pseudoephedrine
Preparation Products	BOC-D-Leucine monohydrate-->BOC-D-LEUCINOL-->D-Alanine

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