2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone
  • CAS No.:86404-63-9
Other grades of this product :
2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone Basic information
Product Name:2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone
Synonyms:Triazole Acetophenone;2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone 95%;Imp. E (EP): 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone;2-(1H-1,2,4-Triazol-1-yl)-2',4'-difluoroacetophenone,98%;2,4-DIFLUORO-ALPHA, ALPHA-BIS(1H-1,2,4-T RIAZOL-1YL METHYL)BENZYL ALCOHOL;1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one;α-(1H-1,2,4-Triazole-1-yl)-2',4'-difluoroacetophenone;Difluoro triazolyl acetophenone
CAS:86404-63-9
MF:C10H7F2N3O
MW:223.18
EINECS:617-850-9
Product Categories:Heterocycles;Building Blocks;Amines;Aromatics;Heterocyclic Building Blocks;Triazoles;Chemical Amines
Mol File:86404-63-9.mol
2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone Chemical Properties
Melting point 103-107 °C(lit.)
Boiling point 388.0±52.0 °C(Predicted)
density 1.39±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka2.05±0.10(Predicted)
color White to pale brown
CAS DataBase Reference86404-63-9(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 3
HS Code 29339900
MSDS Information
ProviderLanguage
SigmaAldrich English
2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone Usage And Synthesis
Chemical PropertiesPale Yellow Solid
UsesAntifungal activity, particularly toward Candida albicans and Candida parapsilosis
Uses2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone (Voriconazole EP Impurity A; Voriconazole USP Related Compound C) is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis
2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone Preparation Products And Raw materials
Raw materials4-Chloro-6-ethyl-5-fluoropyrimidine-->(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

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