2,6-Dichlorobenzyl bromide

CAS No.：20443-98-5

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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2,6-Dichlorobenzyl bromide Basic information

Product Name:	2,6-Dichlorobenzyl bromide
Synonyms:	alpha-Bromo-2,6-dichlorotoluene, 2-(Bromomethyl)-1,3-dichlorobenzene;2,6-two chlorobenzyl broMide;A-BROMO-2,6-DICHLOROTOLUENE;ALPHA-BROMO-2,6-DICHLOROTOLUENE;2-(BROMOMETHYL)-1,3-DICHLOROBENZENE;2,6-DICHLOROBENZYL BROMIDE;1-BROMOMETHYL-2,6-DICHLOROBENZENE;DICHLOROBENZYL(2,6-) BROMIDE
CAS:	20443-98-5
MF:	C7H5BrCl2
MW:	239.92
EINECS:	243-827-4
Product Categories:
Mol File:	20443-98-5.mol

2,6-Dichlorobenzyl bromide Chemical Properties

Melting point	54-56 °C(lit.)
Boiling point	>110°C
density	1.5832 (rough estimate)
refractive index	1.5700 (estimate)
Fp	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	methanol: 0.1 g/mL, clear
form	Crystals or Crystalline Powder
color	Colorless to white
BRN	637351
CAS DataBase Reference	20443-98-5(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 2-(bromomethyl)-1,3-dichloro-(20443-98-5)

Safety Information

Hazard Codes	C
Risk Statements	34-36/37-36
Safety Statements	22-26-27-28-36/37/39-45-25
RIDADR	UN 3261 8/PG 2
WGK Germany	3
RTECS	XS7966000
F	19
HazardClass	8
PackingGroup	II
HS Code	29039990

MSDS Information

Provider	Language
2,6-Dichlorobenzyl bromide	English
ACROS	English
SigmaAldrich	English
ALFA	English

2,6-Dichlorobenzyl bromide Usage And Synthesis

Chemical Properties	White solid
Uses	2,6-Dichlorobenzyl Bromide is used in the preparation of potent epoxide hydrolase inhibitors. Has shown thus far to relieve hypotension in lipopolysaccharide deficient murine models. As well they have been used in the synthesis of anti-HIV drugs based on diaryltriazine (DATA) analogues.
Synthesis Reference(s)	Tetrahedron Letters, 29, p. 707, 1988 DOI: 10.1016/S0040-4039(00)80190-2

2,6-Dichlorobenzyl bromide Preparation Products And Raw materials

Preparation Products

2-[(2,6-DICHLOROBENZYL)OXY]BENZALDEHYDE-->2-Oxazolidinone, 3-[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]-5-(2,2-diMethyl-4H-1, 3-benzodioxin-6-yl)-, (5R)--->2,6-DICHLOROBENZYL METHYL ETHER-->1-(2,6-DICHLOROBENZYL)PIPERAZINE

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