3-Amino-5-fluoropyridine

CAS No.：210169-05-4

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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3-Amino-5-fluoropyridine Basic information

Product Name:	3-Amino-5-fluoropyridine
Synonyms:	3-AMINO-5-FLUOROPYRIDINE;3-Pyridinamine,5-fluoro-(9CI);3-AMINO-5-FLUOROPYRIDINE 97%;5-Fluoropyridin-3-amine;5-Fluoropyridin-3-ylamine;3-Amine-5-fluoro-pyridin;3-AMine-5-fluoro-pyridine;3-PyridinaMine,5-fluoro-
CAS:	210169-05-4
MF:	C5H5FN2
MW:	112.11
EINECS:	664-255-5
Product Categories:	Fluorine series;Building Blocks;C5;C5 to C6;Chemical Synthesis;Fluorinated Building Blocks;PYRIDINE;Pyridine series;Pyridines;Boronic Acid;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;AMINEPRIMARY;HALIDE
Mol File:	210169-05-4.mol

3-Amino-5-fluoropyridine Chemical Properties

Melting point	86°C
Boiling point	232.7±20.0 °C(Predicted)
density	1.257±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	powder to crystal
pka	3.74±0.20(Predicted)
color	Light orange to Yellow to Green
CAS DataBase Reference	210169-05-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	20/21/22-36/37/38-22
Safety Statements	26-36-36/37
WGK Germany	3
HazardClass	IRRITANT
HS Code	2933399990

MSDS Information

3-Amino-5-fluoropyridine Usage And Synthesis

Chemical Properties	Light yellow Crystal
Uses	3-amino-5-fluoropyridine is an important intermediate mainly used in medicine and organic synthesis. It is used to synthesize Ivosidenib. Ivosidenib is an isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults.
Application	Reactant for:Preparation of nonpeptide inhibitors of measles virus entry.
Preparation	synthesis of 3-Amino-5-fluoropyridine: A solution of 3-amino-2,4,6-tribromo-5-fluoropyridine (23c) (0.9 g, 2.6 mmol), triethylamine (1.1 cm3, 7.9 mmol), palladium catalyst (0.1 g of 5% Pd-C catalyst) and DCM (15 cm3) was hydrogenated on a Parr apparatus for 18 h. Water (20 cm3) was added and the mixture filtered and extracted into DCM. The DCM solution was dried (MgS04) and evaporated giving 3-amino-5-fluoropyridine (0.3 g, >95% ), m.p. 86 ·c (from DCM) (Found: C, 53.6; H, 4.6; N, 25.0. C5H5FN2 requires C, 53.6; H, 4.5 N, 25.0%);IR spectrum no. 9; mass spectrum no. 5; nmr spectrum no. 29.

3-Amino-5-fluoropyridine Preparation Products And Raw materials

Raw materials

Ethanol-->Hydrochloric acid-->Methanol-->Diethyl ether-->Hexane-->Palladium-->Fluoroboric acid-->1,2-Dichloroethane-->Benzyl alcohol-->Ammonium formate-->4-Methylmorpholine-->Diphenylphosphoryl azide-->5-Methylpyridin-3-amine-->Isoamyl nitrite-->5-Fluoronicotinic acid-->Carbamic acid, N-(5-fluoro-3-pyridinyl)-, phenylmethyl ester-->2,6-DICHLORO-5-FLUORONICOTINOYL CHLORIDE-->2,4,6-TRIBROMO-3,5-DIFLUOROPYRIDINE

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