Chloromethyltrimethylsilane

CAS No.：2344-80-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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Chloromethyltrimethylsilane Basic information

Product Name:	Chloromethyltrimethylsilane
Synonyms:	CHLOROMETHYLTRIMETHYLSILANE;Chloromethyltrimethylsilane, 98+%;Silane, (chloromethyl)trimethyl-;chlormethyl-trimethyl-silane;Chloro(trimethylsilyl)methane;ChloroMethyltriMethylsilane, 98+% 100GR;ChloroMethyltriMethylsilane, 98+% 25GR;(CHLOROMETHYL)TRIMETHYLSILANE FOR SYNTHE
CAS:	2344-80-1
MF:	C4H11ClSi
MW:	122.67
EINECS:	219-058-5
Product Categories:	pharmacetical;Halides;Si (Classes of Silicon Compounds);Si-(C)4 Compounds;Silicon Compounds (for Synthesis);Synthetic Organic Chemistry;Chemical Synthesis;Organometallic Reagents;Organosilicon;Others
Mol File:	2344-80-1.mol

Chloromethyltrimethylsilane Chemical Properties

Melting point	<0°C
Boiling point	98-99 °C(lit.)
density	0.88 g/mL at 20 °C
vapor pressure	~25 mm Hg ( 20 °C)
refractive index	n20/D1.418(lit.)
Fp	27 °F
storage temp.	Store below +30°C.
form	Liquid
Specific Gravity	0.879
color	Clear colorless
Water Solubility	insoluble
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	4: no reaction with water under neutral conditions
BRN	906705
CAS DataBase Reference	2344-80-1(CAS DataBase Reference)
NIST Chemistry Reference	Silane, (chloromethyl)trimethyl-(2344-80-1)
EPA Substance Registry System	Silane, (chloromethyl)trimethyl- (2344-80-1)

Safety Information

Hazard Codes	F,Xi,C
Risk Statements	11-36/37/38-34
Safety Statements	16-26-36-29-37/39-33
RIDADR	UN 1993 3/PG 2
WGK Germany	3
F	10-21
Hazard Note	Irritant/Highly Flammable
TSCA	Yes
HazardClass	3
PackingGroup	II
HS Code	29310095

MSDS Information

Provider	Language
Chloromethyltrimethylsilane	English
SigmaAldrich	English
ACROS	English
ALFA	English

Chloromethyltrimethylsilane Usage And Synthesis

Chemical Properties	CLEAR COLOURLESS LIQUID
Uses	(Chloromethyl)trimethylsilane is used for Wittig reaction and building blocks.
Uses	(Chloromethyl)trimethylsilane can be treated with aldehydes or ketones in the presence of triphenylphosphine to synthesize terminal alkenes. It can also be used in the preparation of a reagent, trimethylsilylmethyl magnesium chloride, commonly used in Peterson methylenation.

Chloromethyltrimethylsilane Preparation Products And Raw materials

Raw materials	Chloro(chloromethyl)dimethylsilane-->Bromochloromethane-->(Chloromethyl)trichlorosilane-->METHYLMAGNESIUM IODIDE-->Tetramethylsilane
Preparation Products	(TRIMETHYLSILYL)DIAZOMETHANE-->N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine-->TRIMETHYLSILYLMETHYL ACETATE-->(METHOXYMETHYL)TRIMETHYLSILANE-->1,3-Bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane-->TRIMETHYLSILYLMETHYLMAGNESIUM CHLORIDE

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