2-Methyl-2-thiopseudourea sulfate

CAS No.：867-44-7

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2-Methyl-2-thiopseudourea sulfate Basic information

Product Name:	2-Methyl-2-thiopseudourea sulfate
Synonyms:	s-methylthiouroniumsulfate(2:1);S-METHYL-ISO-THIOUREA;S-MethyliSothourea Sulfate;S-METHYLISOTHIOUREA HEMISULFATE NITRIC O XIDE SYNTHASE;S-Methylthioureasulfate=2-Methyl-2-thiopseudoureasulfate;2-Methyl-2-thiopseudourea sulphate;S-EIT hemihydrate;S-Methylisothiouroniumsulfate,98%
CAS:	867-44-7
MF:	C2H8N2O4S2
MW:	188.23
EINECS:	212-759-7
Product Categories:	Cell Signaling and Neuroscience;Nitric Oxide and Cell Stress;Nitric Oxide Metabolism;Nitric Oxide Synthase Regulators;Bioactive Small Molecules;Building Blocks;pharmacetical;Nitric Oxide;Cell Biology;Chemical Synthesis;M;Organic Building Blocks;Sulfur Compounds;Thioureas
Mol File:	867-44-7.mol

2-Methyl-2-thiopseudourea sulfate Chemical Properties

Melting point	240-241 °C (dec.)(lit.)
density	1.28
Fp	3℃
storage temp.	Inert atmosphere,Room Temperature
solubility	H₂O: 0.1 g/mL, clear, colorless
pka	pK1:9.83(＋1) (25°C)
form	Crystals or Crystalline Powder
color	White
PH	5.5 (260g/l, H2O, 20℃)
Water Solubility	260 g/L (20 ºC)
Sensitive	Hygroscopic
BRN	3917217
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	867-44-7(CAS DataBase Reference)
EPA Substance Registry System	Carbamimidothioic acid, methyl ester, sulfate (2:1) (867-44-7)

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	22-24/25
WGK Germany	3
RTECS	UM9200000
TSCA	Yes
HS Code	29309070

MSDS Information

Provider	Language
2-Methyl-2-thiopseudourea sulfate	English

2-Methyl-2-thiopseudourea sulfate Usage And Synthesis

Description	SMIT is a potent non-selective inhibitor of NOS isoforms in vitro but may lack good in vivo efficacy due to poor cellular penetration. The K_i values are 120, 200, and 160 nM using purified human iNOS, eNOS, and nNOS, respectively.
Chemical Properties	white crystalline powder
Uses	Intermediate of 4-Hydroxydebrisoquine. S-Methyl-isothiouronium Hemisulfate is also a reagent used in the synthesis of strobilurin-pyrimidine derivatives for their anti-proliferative activity.
Biochem/physiol Actions	More potent than NMMA as an inhibitor of inducible nitric oxide synthetase (iNOS).

2-Methyl-2-thiopseudourea sulfate Preparation Products And Raw materials

Preparation Products

5-methoxy-2-(methylthio)pyrimidin-4-ol ,97%-->4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile ,97%-->1-Methyl-3-nitro-1-nitrosoguanidine-->ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE-->Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate-->Aminoguanidine bicarbonate-->1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER-->IMINOCTADINE TRIACETATE-->5-CHLORO-2-METHOXYPYRIMIDINE-4-CARBOXYLIC ACID-->1,1-DIMETHYLGUANIDINE SULFATE-->5-[2-(METHYLTHIO)PYRIMIDIN-4-YL]THIOPHENE-2-SULFONYL CHLORIDE-->5-Chloro-2-(methylsulfonyl)pyrimidine-->METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97-->4-Methoxy-6-methyl-2-(methylsulfonyl)pyrimidine ,97%-->5-CHLORO-2-(METHYLSULFONYL)PYRIMIDINE-4-CARBOXYLIC ACID-->5-Bromo-4-chloro-2-(methylthio)-7H-pyrrolo[2,3-D]pyrimidine ,97%-->5-BROMO-2-(METHYLSULFONYL)PYRIMIDINE-4-CARBOXYLIC ACID-->2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE-->4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid ,97%-->4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile-->3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER-->5-AMINOPYRIMIDINE-->5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid-->ethyl 2-(methylsulfanyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate-->4-Methoxy-6-methyl-2-(methylthio)pyrimidine-->4-METHYL-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER-->2-(METHYLSULFANYL)-5-PHENYLPYRIMIDINE-->5-Methyl-2-(methylsulfonyl)pyrimidine ,97%-->Aminoguanidinium sulphate-->2-(METHYLTHIO)ETHANOL-->1-(4-METHYL-2-(METHYLTHIO)PYRIMIDIN-5-YL)ETHANONE-->Gabexate mesylate-->4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID-->ETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE-->5-METHYL-2-METHYLSULFANYL-PYRIMIDINE

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