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| BETA-PSEUDOURIDINE Basic information |
| BETA-PSEUDOURIDINE Chemical Properties |
| Melting point | 222 °C | | density | 1.641±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Methanol (Very Slightly, Heated), Water (Slightly, Sonicated, Heated) | | pka | 8.52±0.10(Predicted) | | form | Solid | | color | White to Off-White | | λmax | 264nm(MeOH)(lit.) |
| BETA-PSEUDOURIDINE Usage And Synthesis |
| Description | β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine . It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. β-pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner. | | Uses | An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes. | | Definition | ChEBI: A C-glycosyl pyrimidine that consists of uracil having a beta-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine. |
| BETA-PSEUDOURIDINE Preparation Products And Raw materials |
| Raw materials | 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[(1,1-dimethylethyl)diphenylsilyl]-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]--->D-Ribitol, 1,4-anhydro-1-C-(2,4-dimethoxy-5-pyrimidinyl)-, (1S)--->PSEUDOURIDINE NATURAL B ISOMER*FROM WHEAT BRAN-->2,4(1H,3H)-Pyrimidinedione, 5-[2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]--->2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[(1,1-dimethylethyl)diphenylsilyl]-β-D-ribofuranosyl]--->5-O-(1-Methoxy-1-Methylethyl)-2,3-O-(1-Methylethylidene)-D-ribonic Acid γ-Lactone-->PSEUDOISOCYTIDINE-->D(+)-Ribonic acid gamma-lactone |
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