2-Oxazolidone

2-Oxazolidone
  • CAS No.:497-25-6
Other grades of this product :
2-Oxazolidone Basic information
Product Name:2-Oxazolidone
Synonyms:2-Oxotetrahydro-1,3-oxazole;2-Oxazolinone;2-Oxazolidone,98%;2-Oxazolidone, 98% 100GR;2-Oxazolidone, 98% 25GR;2-Oxo-1,3-oxazolidine;NSC 35382;NSC 38240
CAS:497-25-6
MF:C3H5NO2
MW:87.08
EINECS:207-840-9
Product Categories:Building Blocks;Heterocyclic Building Blocks;Oxazolines/Oxazolidines;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:497-25-6.mol
2-Oxazolidone Chemical Properties
Melting point 83-87 °C(lit.)
Boiling point 220 °C48 mm Hg(lit.)
density 1.2736 (rough estimate)
refractive index 1.4940 (estimate)
Fp 220°C/48mm
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly, Heated), Methanol (Slightly)
form Crystals or Powder
pka12.78±0.20(Predicted)
color Off-white to yellow-beige
Water Solubility Soluble in water.
BRN 106251
CAS DataBase Reference497-25-6(CAS DataBase Reference)
NIST Chemistry ReferenceOxazolidin-2-one(497-25-6)
EPA Substance Registry System2-Oxazolidinone (497-25-6)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36-43-40-36/37/38
Safety Statements 26-36/37-37-36
WGK Germany 3
RTECS RQ2450000
TSCA Yes
HS Code 29322980
ToxicityTDLo orl-mus: 1000 mg/kg:ETA BCPCA62,168,59
MSDS Information
ProviderLanguage
Oxazolidin-2-one English
SigmaAldrich English
ACROS English
ALFA English
2-Oxazolidone Usage And Synthesis
Chemical Propertiesoff-white to yellow-beige crystals or powder
UsesAs an oxazole derivative used as an antibiotic, 2-Oxazolidone is also used in the preparation of compounds with antitumor activity and as a metabolite of Furazolidone (F864100).
UsesAn oxazole derivative used as an antibiotic. It is also used in the preparation of compounds with antitumor activity. A metabolite of Furazolidone (F864100).
DefinitionChEBI: An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.
Safety ProfileQuestionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.
Purification MethodsCrystallise it from *benzene, dichloroethane, CHCl3 or EtOH. It is a cyclic urethane, and as such it is not very stable. [Katritzky et al. J Chem Soc Perkin II 145 1990, Beilstein 27 H 135, 27 II 259, 27 III/IV 2516.]

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