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| Product Name: | Bromoacetaldehyde dimethyl acetal | | Synonyms: | Ethane,2-broMo-1,1-diMethoxy-;2-BroMo-1,1-diMethoxyethane, 98%+;2-Bromo-1,1-dimethoxyethane
2,2-Dimethoxyethyl Bromide;2 - broMine - 1, 1 - diMethoxy ethane;BROMOACETALDEHYDE DIMETHYL ACETAL (BADA);Bromoacetaldehyde dimethyl acetal, 97+%, stab. with potassium carbonate;Bromoacetaldehyde Dimethyl Acetal (stabilized with K2CO3);Bromoacetoaldehyde dimethyl acetal ,98% | | CAS: | 7252-83-7 | | MF: | C4H9BrO2 | | MW: | 169.02 | | EINECS: | 230-669-6 | | Product Categories: | Aromatic Aldehydes & Derivatives (substituted);Other Products;Pharmaceutical Intermediates;bc0001;7252-83-7 | | Mol File: | 7252-83-7.mol |
| Bromoacetaldehyde dimethyl acetal Chemical Properties |
| Bromoacetaldehyde dimethyl acetal Usage And Synthesis |
| Description | 2-Bromo-1,1-dimethoxyethane (Bromoacetaldehyde dimethyl acetal) is used in the synthesis of 2,3-O-acetal via reaction with 2,3-diol in the presence of 10-camphorsulphonic acid (CSA). 2-bromo-1,1-dimethoxyethane was used to react with 4-hydroxylbenzaldehyde, and finally aldehyde substituted prodrug was generated by TFA-mediated deacetalization. It is widely used in chemistry for the synthesis of a variety of antibiotics (including erythromycin and cephalosporins) and other drugs. It is an important and highly reactive bifunctional compound with a good leaving group and a masked aldehyde function. It can be used as a starting material in a variety of reactions to provide N-alkylated compounds, lactams, aldehydes, oximes, azides, and acyclic di-/polyselenides.
| | Reference | Gotkowska, Joanna. "Bromoacetaldehyde Diethyl Acetal." Synlett26.15(2015):2185-2186.
| | Chemical Properties | clear colourless to light yellow liquid | | Uses | 2-Bromo-1,1-dimethoxyethane (Bromoacetaldehyde dimethyl acetal) was used in the synthesis of 2,3-O-acetal via reaction with 2,3-diol in the presence of 10-camphorsulphonic acid (CSA). 2-bromo-1,1-dimethoxyethane was used to react with 4-hydroxylbenzaldehyde, and finally aldehyde substituted prodrug was generated by TFA-mediated deacetalization. | | Uses | 2-Bromo-1,1-dimethoxyethane (Bromoacetaldehyde dimethyl acetal) was used in the synthesis of 2,3-O-acetal via reaction with 2,3-diol in the presence of 10-camphorsulphonic acid (CSA). |
| Bromoacetaldehyde dimethyl acetal Preparation Products And Raw materials |
| Raw materials | 1,2-Dibromo-1-ethoxyethane-->Paraldehyde | | Preparation Products | 1-BENZOTHIOPHENE-5-CARBOXYLIC ACID-->BENZOFURAN-5-BORONIC ACID-->2-(1-BENZOTHIOPHEN-5-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE-->(5-BROMO-3-BENZO[B]THIENYL)METHANOL-->(5-CHLORO-1-BENZOTHIOPHEN-3-YL)METHANOL-->5-BROMOBENZO[B]THIOPHENE-3-CARBOXYLIC ACID-->5-CHLORO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID-->1-BENZOTHIOPHENE-5-CARBONYL CHLORIDE-->1-(1,3-DIOXOLAN-2-YLMETHYL)PIPERAZINE-->1-(5-BROMO-1-BENZOTHIEN-3-YL)ETHANONE-->3-Acetyl benz[b]thiophene-->1-(5-CHLOROBENZO[B]THIOPHEN-3-YL)ETHANONE-->5-CHLOROBENZOTHIOPHENE-->7-CYANO-BENZO[B]THIOPHENE-->2,2'-METHYLIMINOBIS-(ACETALDEHYDE DIMETHYL ACETAL)-->6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE-->Methoxyethene-->Oxazole-2-amine |
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