5-Methyl-2-pyrazinecarboxylic acid

CAS No.：5521-55-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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5-Methyl-2-pyrazinecarboxylic acid Basic information

Product Name:	5-Methyl-2-pyrazinecarboxylic acid
Synonyms:	5-Methylpyrazine-2-carboxylicacid(Acipimoxintermediate);5-Methyl-2-pyrazinecarboxylic acid,99%;5--2- Methylpyrazine carboxylic acid;5-Methyl-2-pyrazinecarboxylic acid 98%;Methyl-2-pyrazinecarboxylic;2-Methyl-5-Pyrazine-Carboxylic Acid (5MPC);5-Methylparazine-2-carboxylic acid;2-Carboxy-5-methylpyrazine
CAS:	5521-55-1
MF:	C6H6N2O2
MW:	138.12
EINECS:	413-260-9
Product Categories:	Mono- & Polyalkylpyrazines;Pyrazinecarboxylic Acid & Derivatives;Aromatics;Bases & Related Reagents;Building Blocks;Heterocyclic Building Blocks;Carboxylic Acids;Pyrazines, Pyrimidines & Pyridazines;Organic acids;Aromatics Compounds;Pyrazines;Nucleotides;Carboxylic Acids;Pyrazines, Pyrimidines & Pyridazines;Acids and Derivatives;Heterocycles;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
Mol File:	5521-55-1.mol

5-Methyl-2-pyrazinecarboxylic acid Chemical Properties

Melting point	167-171 °C(lit.)
Boiling point	253.51°C (rough estimate)
density	1.3471 (rough estimate)
refractive index	1.5100 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Amorphous Powder
pka	3.53±0.10(Predicted)
color	Orange
BRN	116005
CAS DataBase Reference	5521-55-1(CAS DataBase Reference)
NIST Chemistry Reference	2-Methylpyrazine-5-carboxylic acid(5521-55-1)

Safety Information

Hazard Codes	Xi
Risk Statements	41-36/37/38
Safety Statements	26-39-36
WGK Germany	1
Hazard Note	Irritant
HS Code	29339990

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

5-Methyl-2-pyrazinecarboxylic acid Usage And Synthesis

Chemical Properties	Pale Brown Powder
Uses	5-Methyl-2-pyrazinecarboxylic acid may be used in the preparation of novel europium(III) complexes, (5-methyl-2-pyrazinecarboxylato) (phenanthroline)europium(III). It may be used in the synthesis of Ln-metal organic frameworks (MOFs).
General Description	5-Methyl-2-pyrazinecarboxylic acid is a pyrazine derivative. Simultaneous membrane based solvent extraction (MBSE) and membrane based solvent stripping (MBSS) of 5-methyl-2-pyrazine carboxylic acid (MPCA) has been studied. Mechanism of pertraction of MPCA through layered bulk liquid membranes has been studied. MPCA reacts with Ln(NO₃)₃·6H₂O and K₄[W(CN)₈]·2H₂O to form unique three-dimensional network structure which contains open channels.
Synthesis	5-Methylpyrazine-2-carboxylic acid is an intermediate of the lipid-lowering drug amoximus. It can be prepared by electrolytic oxidation of 2,5-dimethyl or 2-methyl-5-(substituted) methylpyrazine.

5-Methyl-2-pyrazinecarboxylic acid Preparation Products And Raw materials

Raw materials	2-Methylpyrazine-->Pyrazinemethanol, 5-methyl-, acetate (ester)-->3-HYDROXY-5-METHYLPYRAZINE-2-CARBOXYLIC ACID-->diethyl pyrazine-2,5-dicarboxylate-->PYRAZINE-2,5-DICARBOXYLIC ACID-->2-(chloromethyl)-5-methylpyrazine hydrochloride-->5-Methyl-2,3-pyrazinedicarboxylic acid-->2-(CHLOROMETHYL)-5-METHYLPYRAZINE-->5-Methyl-2-pyrazinemethanol-->Pyrazinecarboxamide, 3,4-dihydro-5-methyl-3-oxo- (9CI)
Preparation Products	Acipimox-->2-Pyrazinecarboxylic acid-->2-Bromo-5-methylpyrazine-->METHYL 5-METHYLPYRAZINE-2-CARBOXYLATE

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