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| Sodium propylparaben Basic information |
| Product Name: | Sodium propylparaben | | Synonyms: | SODIUM PROPYL 4-HYDROXYBENZOATE;SODIUM PROPYL HYDROXYBENZOATE;Sodium propylparaben;SolbrolP,Natriumsalz;PROPYLPARABENSODIUM,NF;PROPYL4-HYDROXYBENZOATESODIUMSALT(PROPYLPARABENSODIUMSALT);Sodiumpropylester4-hydroxybenzoate;SOIDUM PROPYLPARABEN | | CAS: | 35285-69-9 | | MF: | C10H11NaO3 | | MW: | 202.18 | | EINECS: | 252-488-1 | | Product Categories: | API;Cosmetics;Aromatic Esters | | Mol File: | 35285-69-9.mol |
| Sodium propylparaben Chemical Properties |
| Melting point | 302°C | | density | 1.24 g/cm3 (25 °C) | | vapor pressure | 0.001Pa at 20℃ | | storage temp. | Store at +15°C to +25°C. | | solubility | Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. | | form | Solid | | pka | 8.46[at 20 ℃] | | color | White to Off-White | | PH | 9.5-10.5 (1g/l, H2O, 20°C) | | Water Solubility | 1000g/L at 23℃ | | Stability: | Hygroscopic | | LogP | 0.27 at 23℃ | | CAS DataBase Reference | 35285-69-9(CAS DataBase Reference) | | EPA Substance Registry System | Propylparaben sodium (35285-69-9) |
| Safety Statements | 22-24/25 | | WGK Germany | 2 | | RTECS | DH2850000 | | HS Code | 2918 29 00 | | Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
| Sodium propylparaben Usage And Synthesis |
| Chemical Properties | White or almost white, hygroscopic, crystalline powder. | | Chemical Properties | Propylparaben sodium occurs as a white, crystalline, odorless or
almost odorless powder. | | Uses | Pharmaceutic aid (antimicrobial preservative). | | Uses | Sodium Propylparaben is a preservative. Sodium Propylparaben is also an excipient used in various pharmaceutical formulations. | | Production Methods | Propylparaben sodium is produced from benzoic acid. | | Flammability and Explosibility | Notclassified | | Pharmaceutical Applications | Propylparaben sodium is used as an antimicrobial or antifungal
preservative in oral pharmaceuticals and in many water-based
cosmetics. It is generally used in combination with other paraben
esters. | | Contact allergens | This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid
and an alcohol. They are largely used as biocides in
cosmetics and toiletries, medicaments, or food. They
have synergistic power with other biocides. Parabens
can induce allergic contact dermatitis, mainly in
chronic dermatitis and wounded skin. | | Safety | Propylparaben sodium is used in oral pharmaceuticals and
cosmetics. The pure form is toxic by the IV route and moderately
toxic by ingestion and the IP route. Propylparaben sodium may
cause asthma, rashes, and hyperactivity.
LD50 (mouse, IP): 0.49 g/kg
LD50 (mouse, IV): 0.18 g/kg
LD50 (mouse, oral): 3.7 g/kg | | storage | Propylparaben sodium is stable under normal conditions. It
decomposes on heating. Store in a tightly closed container. | | Incompatibilities | The activity of propylparaben sodium can be adversely affected by
the presence of other excipients or active ingredients, such as
atropine, essential oils, iron, magnesium trisilicate, talc, polysorbate
80 and other nonionic surfactants, sorbitol, weak alkalis, and
strong acids. | | Regulatory Status | Included in the FDA Inactive Ingredients Database (oral capsules,
tablets, suspensions). Accepted for use as a food additive in Europe.
Included in nonparenteral medicines (oral capsules, mixtures,
orodispersible tablets, solutions and suspensions; cutaneous emulsions)
licensed in the UK. |
| Sodium propylparaben Preparation Products And Raw materials |
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