Product

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

CAS No.：648450-29-7

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5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Basic information

Product Name:	5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
Synonyms:	5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione;AS605240;5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione;PI 3-Kinase Inhibitor (AS605240) B-0301;AS-605240, >=98%;(E)-5-(quinoxalin-6-ylMethylene)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-(6-quinoxalinylMethylene)-;AS-605240(AS 605240)
CAS:	648450-29-7
MF:	C12H7N3O2S
MW:	257.27
EINECS:
Product Categories:	Inhibitors;API;Akt;mTOR;PI3K
Mol File:	648450-29-7.mol

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Chemical Properties

density	1.553±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble1mg/mL, clear (warmed)
pka	6.02±0.20(Predicted)
form	powder
color	, faint red to orange to dark brown

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
WGK Germany	3
HS Code	2934100090

MSDS Information

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Usage And Synthesis

Uses	AS605240 has been used: as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles. as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction. as a class 1A PI3K inhibitor?to treat CD4⁺?T cells.
Biological Activity	Potent and selective inhibitor of PI 3-kinase γ (PI3K γ ) (IC 50 = 8 nM). Displays 30-fold selectivity over PI3K δ and PI3K β and 7.5-fold selectivity over PI3K α . Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.
Biochem/physiol Actions	AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.
references	[1]. camps m, rückle t, ji h, et al. blockade of pi3kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis[j]. nature medicine, 2005, 11(9): 936-943.[2]. marone r, cmiljanovic v, giese b, et al. targeting phosphoinositide 3-kinase—moving towards therapy[j]. biochimica et biophysica acta (bba)-proteins and proteomics, 2008, 1784(1): 159-185.

5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Preparation Products And Raw materials

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