5-(4-CHLOROPHENYL)-2-FURALDEHYDE

CAS No.：34035-03-5

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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5-(4-CHLOROPHENYL)-2-FURALDEHYDE Basic information

Product Name:	5-(4-CHLOROPHENYL)-2-FURALDEHYDE
Synonyms:	AURORA KA-4235;ART-CHEM-BB B004122;ASISCHEM N16482;5-(4-CHLOROPHENYL)FURFURAL;5-(4-CHLORO-PHENYL)-FURAN-2-CARBALDEHYDE;5-(4-CHLOROPHENYL)-2-FURALDEHYDE;5-(4-CHLOROPHENYL)-2-FURANCARBOXALDEHYDE;AKOS BAR-0548
CAS:	34035-03-5
MF:	C11H7ClO2
MW:	206.63
EINECS:
Product Categories:	API intermediates
Mol File:	34035-03-5.mol

5-(4-CHLOROPHENYL)-2-FURALDEHYDE Chemical Properties

Melting point	128-131 °C (lit.)
Boiling point	350.7±32.0 °C(Predicted)
density	1.282±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	Needles
color	Pale brown
CAS DataBase Reference	34035-03-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29321900

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

5-(4-CHLOROPHENYL)-2-FURALDEHYDE Usage And Synthesis

Chemical Properties	Pale brown needles
Uses	5-(4-Chlorophenyl)furfural is a metabolite of Azimilide (A926950, 2 HCl); an oral type III potassium channel blocker agent that blocks both the rapid activating component and the slow activating component of the delayed rectifier potassium current. Both preclinical and clinical studies have demonstrated the efficacy of Azimilide and its safety in the treatment of supraventricular and ventricular tachyarrhythmia. Azimilide is also being studied in a worldwide multicenter trial for prevention of sudden cardiac death in patients after myocardial infarction.
Uses	5-(4-Chlorophenyl)furfural was used as one of the aldehydes in the synthesis of uridine-based library.
General Description	5-(4-Chlorophenyl)furfural is a furfural derivative.

5-(4-CHLOROPHENYL)-2-FURALDEHYDE Preparation Products And Raw materials

Raw materials

4-chlorobenzenediazonium-->tris(4-chlorophenyl)bismuthane-->5-(4-CHLOROPHENYL)-2-FUROIC ACID-->5-Bromo-2-furaldehyde-->2-Formylfuran-5-boronic acid-->4-Chlorophenylboronic acid-->1-Chloro-4-iodobenzene-->Furfural

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