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| NG-MONOMETHYL-L-ARGININE ACETATE Basic information |
| NG-MONOMETHYL-L-ARGININE ACETATE Chemical Properties |
| Melting point | 180-190 °C | | alpha | D22 +9.5° (c = 0.10 in water) | | Boiling point | 391.35°C (rough estimate) | | density | 1.2162 (rough estimate) | | refractive index | 1.6300 (estimate) | | storage temp. | 2-8°C | | solubility | H2O: 1 mg/mL, clear, colorless | | form | Powder | | color | White to Off-white | | BRN | 6674255 | | Stability: | Store at - 5°C; Desiccate Recommended | | InChIKey | IKPNWIGTWUZCKM-JEDNCBNOSA-N |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29252900 |
| NG-MONOMETHYL-L-ARGININE ACETATE Usage And Synthesis |
| Description | L-NMMA is the archetypal competitive NOS inhibitor to which other inhibitors are often compared. It is a relatively non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 μM, respectively. | | Chemical Properties | White Crystalline Powder | | Uses | A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells | | Uses | Reagent to inhibit nitric oxide production in biological systems. | | Uses | Nitric oxide synthase inhibitor | | Biological Activity | Competitive, irreversible inhibitor of all three NOS isoforms. | | Biochem/physiol Actions | NG-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system. |
| NG-MONOMETHYL-L-ARGININE ACETATE Preparation Products And Raw materials |
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