Boc-N-methyl-L-leucine

CAS No.：53363-89-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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Boc-N-methyl-L-leucine Basic information

Product Name:	Boc-N-methyl-L-leucine
Synonyms:	N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE;N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE;N-ALPHA-T-BUTOXYCARBONYL-BETA-T-BUTYL-L-ALANINE;N-ALPHA-T-BUTOXYCARBONYL-GAMMA-METHYL-L-LEUCINE;N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE;N-ALPHA-T-BOC-N-ALPHA-METHYL-L-LEUCINE;BOC-BETA-TBU-ALANINE;BOC-BETA-TBU-ALA-OH
CAS:	53363-89-6
MF:	C12H23NO4
MW:	245.32
EINECS:
Product Categories:	amino acids;Amino Acid Derivatives;N-Methyl Amino Acids
Mol File:	53363-89-6.mol

Boc-N-methyl-L-leucine Chemical Properties

Melting point	55-60 °C
Boiling point	338.2±21.0 °C(Predicted)
density	1.053±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
pka	4.04±0.21(Predicted)
optical activity	[α]20/D 36±2°, c = 1% in methylene chloride
BRN	2373250
InChIKey	YXJFAOXATCRIKU-VIFPVBQESA-N
CAS DataBase Reference	53363-89-6(CAS DataBase Reference)

Safety Information

WGK Germany	3
HS Code	2924 19 00
HazardClass	IRRITANT

MSDS Information

Boc-N-methyl-L-leucine Usage And Synthesis

Description	Boc-N-methyl-L-leucine is the BOC (tert-butyloxycarbonyl) protected N-methylated leucine. The N-methylated amino acid is quite useful in the peptide synthesis, giving a lot of improved properties to peptide. Studies have shown that peptide containing N-methylated amino acids obtain increased proteolytic stability, increased membrane permeability, and altered conformation. The effects of N-methylated amino acids are quite important in the development of therapeutic peptide compound as well as in the assay of biological activity of some modified peptides. BOC group can be easily removed by treatment with strong acids such as trifluoroacetic acid.
Uses	Boc-N-methyl-L-leucine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.
References	https://en.wikipedia.org/wiki/Tert-Butyloxycarbonyl_protecting_group http://pubs.acs.org/doi/abs/10.1021/cr030024z?src=recsys&journalCode=chreay

Boc-N-methyl-L-leucine Preparation Products And Raw materials

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