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| Estradiol Basic information |
| Product Name: | Estradiol | | Synonyms: | 1,3,5-estratriene-3,17-alpha-diol;1,3,5-Estratriene-3,17alpha-diol;17alpha-Oestradiol;3,17alpha-Dihydroxyestra-1,3,5(10)-triene;3,17-alpha-dihydroxyoestra-1,3,5(10)-triene;3,17alpha-Dihydroxyoestra-1,3,5(10)-triene;5(10)-triene-3,17-diol,(17-alpha)-estra-3;epiestradial | | CAS: | 57-91-0 | | MF: | C18H24O2 | | MW: | 272.39 | | EINECS: | 200-354-8 | | Product Categories: | Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;APIs;57-91-0 | | Mol File: | 57-91-0.mol |
| Estradiol Chemical Properties |
| Melting point | 176-180 °C(lit.) | | alpha | D20 +53 to +56° (c = 0.9 in dioxane) | | Boiling point | 355.44°C (rough estimate) | | density | 1.0708 (rough estimate) | | refractive index | 1.4800 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | ethanol: 50 mg/mL, clear, colorless | | form | powder | | pka | 10.27±0.60(Predicted) | | color | white with slight yellow | | Water Solubility | 3.9mg/L(25 ºC) | | Merck | 14,3704 | | CAS DataBase Reference | 57-91-0(CAS DataBase Reference) | | NIST Chemistry Reference | Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0) | | EPA Substance Registry System | Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0) |
| Estradiol Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke. | | Definition | ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer). | | Biological Activity | Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively). | | Biochem/physiol Actions | Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke. | | Purification Methods | 17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o. |
| Estradiol Preparation Products And Raw materials |
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