Ethyl 2-bromopropionate

CAS No.：535-11-5

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Ethyl 2-bromopropionate Basic information

Product Name:	Ethyl 2-bromopropionate
Synonyms:	2-bromo-propanoicaciethylester;Ethyl 2-broMopropion;Ethyl 2-broMopropionate 99%;Ethyl 2-bromopropiote;Ethyl-bromopropanoate;Propanoicacid,2-bromo-,ethylester;Propionic acid, 2-bromo-, ethyl ester;2-BROMOPROPANOIC ACID ETHYL ESTER
CAS:	535-11-5
MF:	C5H9BrO2
MW:	181.03
EINECS:	208-609-5
Product Categories:	Esters;ACID BASED BROMO COMPOUNDS;C2 to C5;Carbonyl Compounds;Building Blocks;C2 to C5;ester series;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
Mol File:	535-11-5.mol

Ethyl 2-bromopropionate Chemical Properties

Melting point	<25 °C
Boiling point	156-160 °C (lit.)
density	1.394 g/mL at 25 °C (lit.)
refractive index	n20/D 1.446(lit.)
Fp	125 °F
storage temp.	Store below +30°C.
form	Liquid
color	Clear colorless to very slightly yellow
Water Solubility	Immiscible
Merck	14,3772
BRN	773920
InChIKey	ARFLASKVLJTEJD-UHFFFAOYSA-N
CAS DataBase Reference	535-11-5(CAS DataBase Reference)
NIST Chemistry Reference	Propanoic acid, 2-bromo-, ethyl ester(535-11-5)
EPA Substance Registry System	Propanoic acid, 2-bromo-, ethyl ester (535-11-5)

Safety Information

Hazard Codes	C,Xn
Risk Statements	10-34-36/37/38-20/22
Safety Statements	16-26-36/37/39-45-37/39
RIDADR	UN 2920 8/PG 2
WGK Germany	3
RTECS	UA2451730
F	8-19
TSCA	Yes
HazardClass	3
PackingGroup	III
HS Code	29159080
Toxicity	LD50 orally in Rabbit: 281 mg/kg

MSDS Information

Provider	Language
2-Bromopropanoic acid ethyl ester	English
ACROS	English
SigmaAldrich	English
ALFA	English

Ethyl 2-bromopropionate Usage And Synthesis

Chemical Properties	clear colorless to very slightly yellow liquid
Uses	Ethyl 2-Bromopropionate is an intermediate in the synthesis of organic compounds and pharmaceuticals.
Uses	It?s an important organic intermediate can be used in agrochemical, pharmaceutical synthesis and dyestuff field.
Purification Methods	Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beils

Ethyl 2-bromopropionate Preparation Products And Raw materials

Raw materials	Ethanol-->Thionyl chloride-->Propionic acid-->2-Bromopropionyl chloride
Preparation Products	5-METHYLPYRIMIDIN-4-OL-->4-Hydroxy-5-methyl-2-mercaptopyrimidine-->2-(2,4,5-TRICHLOROPHENOXY)PROPIONIC ACID-->2-(2-OXO-2H-CHROMEN-7-YLOXY)-PROPIONIC ACID-->Oxiracetam-->4-CHLORO-5-METHYL-2-METHYLSULFANYL-PYRIMIDINE-->4(3H)-Pyrimidinone, 5-methyl-2-(methylthio)-

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