Product

4-Nitrophenyl chloroformate

CAS No.：7693-46-1

Other grades of this product :

4-Nitrophenyl chloroformate Basic information

Product Name:	4-Nitrophenyl chloroformate
Synonyms:	4-Nitrophenyl chloridocarbonate;CARBONOCHLORIDIC ACID, 4-NITROPHENYL ESTER;CHLOROFORMIC ACID 4-NITROPHENYL ESTER;CHLOROFORMIC ACID P-NITROPHENYL ESTER;4-NITROPHENYL CHLOROCARBONATE;4-NITROPHENYL CHLOROFORMATE;Nitrophenyl chloroforMate;4-Nitrophenyl chloroforMate, 97% 25GR
CAS:	7693-46-1
MF:	C7H4ClNO4
MW:	201.56
EINECS:	231-706-9
Product Categories:	Pharmaceutical intermediates;Protection & Derivatization Reagents (for Synthesis);blocks;BuildingBlocks;NitroCompounds;Synthetic Organic Chemistry;Miscellaneous
Mol File:	7693-46-1.mol

4-Nitrophenyl chloroformate Chemical Properties

Melting point	77-79 °C(lit.)
Boiling point	159-162 °C19 mm Hg(lit.)
density	1.5719 (rough estimate)
refractive index	1.6000 (estimate)
Fp	>110°C
storage temp.	2-8°C
solubility	Soluble in acetone, chloroform, acetone, toluene and benzene.
form	isopropanol suspension
color	White to yellow-beige
Water Solubility	decomposes
Sensitive	Lachrymatory
BRN	518127
Stability:	Stable. Incompatible with strong bases, acids. Combustible.
CAS DataBase Reference	7693-46-1(CAS DataBase Reference)
NIST Chemistry Reference	Carbonochloridic acid, 4-nitrophenyl ester(7693-46-1)
EPA Substance Registry System	Carbonochloridic acid, 4-nitrophenyl ester (7693-46-1)

Safety Information

Hazard Codes	C,T,Xi,F
Risk Statements	34-36/37-23/24/25-41-36/37/38-11-67-36
Safety Statements	26-36/37/39-45-38-28A-36-16-27
RIDADR	UN 3261 8/PG 2
WGK Germany	3
F	19-21
Hazard Note	Toxic/Corrosive/Lachrymator
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29159020

MSDS Information

Provider	Language
4-Nitrophenyl chloroformate	English
ACROS	English
SigmaAldrich	English
ALFA	English

4-Nitrophenyl chloroformate Usage And Synthesis

Chemical Properties	Cream solid
Uses	4-Nitrophenyl Chloroformate is an ester of chloroformic acid used in the immobilization of enzymes and other biomolecules.
Uses	4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane.
Uses	4-Nitrophenyl chloroformate can be used: As a reagent for the activation of amines, alcohols and thiols. In the synthesis of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles). In the solid-phase synthesis of 3-aryl-2,4-quinazolinedione derivatives with potent anti-cancer property. In the preparation of poly(oxyethylene) modified dextrans. To synthesize a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA.

4-Nitrophenyl chloroformate Preparation Products And Raw materials

Preparation Products

Temozolomide-->Z-GLY-ONP-->Z-LEU-ONP-->FMoc-Val-Cit-PAB-PNP-->L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]--->5-AMINO-2-METHYLBENZOTHIAZOLE

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