4-Fluoro-3-nitrobenzoic acid

CAS No.：453-71-4

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

4-Fluoro-3-nitrobenzoic acid Basic information

Product Name:	4-Fluoro-3-nitrobenzoic acid
Synonyms:	4-Carboxy-2-nitrofluorobenzene;5-Carboxy-2-fluoronitrobenzene;4-Fluoro-3-nitrobenzoic acid, 98% 5GR;4-Fluoro-3-nitrobenzoic acid,98%;NSC 10311;4-Fluoro-3-nitrobenzoic Acid, 97+%;Benzoic acid, 4-fluoro-3-nitro-;p-Fluoro-3-nitrobenzoic acid
CAS:	453-71-4
MF:	C7H4FNO4
MW:	185.11
EINECS:	207-221-3
Product Categories:	Benzenes;C7Fluorescent Probes, Labels, Particles and Stains;Carbonyl Compounds;Carboxylic Acids;Fluorescent Labels;Other Fluorescent Labels;Benzoic acid;Miscellaneous;Fluorobenzoic acids;Other Fluorescent Labels;Aryl Fluorinated Building Blocks;Biochemicals and Reagents;Building Blocks;C7;blocks;Carboxes;FluoroCompounds;NitroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid series;Aromatics;Miscellaneous Reagents;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Fluorescent Labels;Fluorescent Probes;Fluorinated Building Blocks;Labels;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Particles and Stains
Mol File:	453-71-4.mol

4-Fluoro-3-nitrobenzoic acid Chemical Properties

Melting point	123-126 °C (lit.)
Boiling point	92°C 15mm
density	1.5071 (estimate)
Fp	92°C/15mm
storage temp.	Sealed in dry,Room Temperature
solubility	95% ethanol: soluble50mg/mL, clear, light yellow
pka	3.54±0.10(Predicted)
form	Powder or Crystals
color	Light yellow to tan
Water Solubility	insoluble
BRN	2107562
CAS DataBase Reference	453-71-4(CAS DataBase Reference)
NIST Chemistry Reference	4-Fluoro-3-nitrobenzoic acid(453-71-4)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38
Safety Statements	26-36-24/25
WGK Germany	2
HazardClass	IRRITANT
HS Code	29163990

MSDS Information

Provider	Language
4-Fluoro-3-nitrobenzoic acid	English
ACROS	English
SigmaAldrich	English
ALFA	English

4-Fluoro-3-nitrobenzoic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

4-Fluoro-3-nitrobenzoic acid was used:

as starting reagent in the preparation of novel benzimidazoles having antimycobacterial activity
in preparation of series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structure
in preparation of bis(heterocyclic) skeletal precursors for the Pictet-Spengler reaction
in solid-phase synthesis of trisubstituted [1,3,5]triazino[1,2-a]benzimidazole-2,4(3H,10H)-diones

4-Fluoro-3-nitrobenzoic acid Preparation Products And Raw materials

Raw materials	4-FLUORO-3-NITROBENZONITRILE-->3-NITRO-4-FLUOROBENZOYL CHLORIDE-->4-Fluoro-3-nitrotoluene-->Azidotrimethylsilane-->4-Fluoronitrobenzene-->4-Fluorobenzaldehyde-->Isopropyl alcohol-->4-Fluorobenzoic acid-->p-Fluorotoluene-->Nitric acid
Preparation Products	ETHYL 3-AMINO-4-(METHYLAMINO)BENZOATE-->4-(cyclohexylamino)-3-nitro-benzoic acid ethyl ester

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873